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Compounds bearing this photoswitchable amino acid become active upon irradiation with red light, but quickly turn\u2010off upon exposure to other visible light wavelengths. Critically, sunlight quickly triggers isomerisation of the red light\u2010activated compounds into their original <jats:italic>trans<\/jats:italic> form, offering an ideal platform for self\u2010deactivation upon release into the environment. Linear analogues of tyrocidine\u2005A were found to provide the best photocontrol of their antimicrobial activity, leading to compounds active against <jats:italic>Acinetobacter baumannii<\/jats:italic> upon isomerisation. Exploration of their <jats:italic>N<\/jats:italic>\u2010 and <jats:italic>C<\/jats:italic>\u2010termini has provided insights into key elements of their structure and has allowed obtaining new antimicrobials displaying excellent strain selectivity and photocontrol.<\/jats:p>","DOI":"10.1002\/chem.202102370","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T07:06:39Z","timestamp":1625555199000},"page":"12987-12991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Controlling Antibacterial Activity Exclusively with Visible Light: Introducing a Tetra\u2010<i>ortho<\/i>\u2010Chloro\u2010Azobenzene Amino Acid"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2182-5960","authenticated-orcid":false,"given":"Xavier","family":"Just\u2010Baringo","sequence":"first","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona) Barcelona Institute of Science and Technology (BIST)  Baldiri Reixac 10 08028 Barcelona Spain"},{"name":"Laboratori de Qu\u00edmica Org\u00e0nica Facultat de Farm\u00e0cia IBUB Universitat de Barcelona  08028 Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Yeste\u2010V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona) Barcelona Institute of Science and Technology (BIST)  Baldiri Reixac 10 08028 Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Moreno\u2010Morales","sequence":"additional","affiliation":[{"name":"Institute for Global Health (ISGlobal) Hospital Cl\u00ednic - Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Ballest\u00e9\u2010Delpierre","sequence":"additional","affiliation":[{"name":"Institute for Global Health (ISGlobal) Hospital Cl\u00ednic - Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Vila","sequence":"additional","affiliation":[{"name":"Institute for Global Health (ISGlobal) Hospital Cl\u00ednic - Universitat de Barcelona  Barcelona Spain"},{"name":"Department of Clinical Microbiology \u2013 CDB Hospital Cl\u00ednic - University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest","family":"Giralt","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona) Barcelona Institute of Science and Technology (BIST)  Baldiri Reixac 10 08028 Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","unstructured":"World Health Organization. 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