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The Ti(IV)\u2010based precursors are composed of two 3,3\u2019\u2010diphenyl\u20102,2\u2019\u2010biphenolato ligands (1) and one substituted 1,10\u2010phenanthroline ligand (2\u20105). The application of imine condensation, palladium\u2010catalyzed C\u2212C bond formation or copper\u2010catalysed azide\u2010alkyne cycloaddition allowed the grafting of various new groups onto these species. In particular Sonogashira reactions permitted to observe an excellent conversion of the starting complexes. This systematic study enabled to compile the factors required to preserve the framework of the complexes in the course of a chemical transformation. Thanks to this chemistry realized on the complex, the Ti(1)<jats:sub>2<\/jats:sub> fragment was used as a protecting group to develop a multi\u2010step synthesis of a bis\u2010phenanthroline compound (12), for which the synthesis without this protection failed. Thus, a dinuclear complex [Ti<jats:sub>2<\/jats:sub>(1)<jats:sub>4<\/jats:sub>(12)] was first prepared starting from complex precursor bearing an acetylenic function <jats:italic>via<\/jats:italic> a Hay coupling reaction. This was followed by a deprotection step affording 12. Overall, this work illustrates how the Ti(1)<jats:sub>2<\/jats:sub> fragment could be an useful tool for the preparation of unprecedented diimine compounds.<\/jats:p>","DOI":"10.1002\/chem.202103235","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T09:18:15Z","timestamp":1636708695000},"page":"17910-17920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chemistry on the Complex: Derivatization of TiO<sub>4<\/sub>N<sub>2<\/sub>\u2010Based Complexes and Application to Multi\u2010Step Synthesis"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8003-9527","authenticated-orcid":false,"given":"Matthieu","family":"Scarpi\u2010Luttenauer","sequence":"first","affiliation":[{"name":"Laboratoire de Synth\u00e8se et fonctions des Architectures Mol\u00e9culaires Universit\u00e9 de Strasbourg CNRS, CMC UMR 7140  67000 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Kyritsakas","sequence":"additional","affiliation":[{"name":"Laboratoire de Tectonique Mol\u00e9culaire Universit\u00e9 de Strasbourg CNRS, CMC UMR 7140  67000 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4563-0375","authenticated-orcid":false,"given":"Alain","family":"Chaumont","sequence":"additional","affiliation":[{"name":"Laboratoire de Mod\u00e9lisation et Simulations Mol\u00e9culaires Universit\u00e9 de Strasbourg CNRS, CMC UMR 7140  67000 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3296-3357","authenticated-orcid":false,"given":"Pierre","family":"Mobian","sequence":"additional","affiliation":[{"name":"Laboratoire de Synth\u00e8se et fonctions des Architectures Mol\u00e9culaires Universit\u00e9 de Strasbourg CNRS, CMC UMR 7140  67000 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2019.213129"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802611794785226"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5DT03919C"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00211"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9DT03587G"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00096D"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00096a028"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT02587A"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8DT03912G"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic030181g"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2016.02.011"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00907G"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3070073"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CC48444K"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201800834"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja204155r"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo990268c"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)94050-4"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35229J"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr500632f"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.8b02049"},{"key":"e_1_2_8_22_1","first-page":"1","volume":"31","author":"Mandal S.","year":"2021","journal-title":"Adv. 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