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Herein, a palladium\u2010catalyzed four\u2010component perfluoroalkylation\/aminocarbonylation of unactivated alkenes with perfluoroalkyl halides, and amines was developed. A wide range of substrates, including anilines, alkylamines, sulfonamides, and hydrazines are all suitable reaction partners for this catalyst system, resulting in various \u03b2\u2010perfluoroalkyl amides with good functional\u2010group tolerance and excellent chemoselectivity. Furthermore, not only alkyl olefins, but also aliphatic alkynes, and even alkyl allenes can all be employed. Notably, several medical and bioactive related molecules are compatible here as well.<\/jats:p>","DOI":"10.1002\/chem.202103391","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T17:55:50Z","timestamp":1633715750000},"page":"17682-17687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Palladium\u2010Catalyzed Carbonylative Four\u2010Component Synthesis of \u03b2\u2010Perfluoroalkyl Amides"],"prefix":"10.1002","volume":"27","author":[{"given":"Youcan","family":"Zhang","sequence":"first","affiliation":[{"name":"Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences  116023 Dalian, Liaoning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Qing","family":"Geng","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Katalyse e.V.  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