{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:55:24Z","timestamp":1790178924252,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"70","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["200021_184608"],"award-info":[{"award-number":["200021_184608"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008375","name":"Universit\u00e4t Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2021,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A ligand\u2010controlled site\u2010selective C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2212H arylation of heteroaromatic ketones has been developed using Pd catalysis. The reaction occurred selectively at the \u03b1\u2010 or \u03b2\u2010position of the ketone side\u2010chain. The switch from \u03b1\u2010 to \u03b2\u2010arylation was realized by addition of a pyridone ligand. The \u03b1\u2010arylation process showed broad scope and high site\u2010 and chemoselectivity, whereas the \u03b2\u2010arylation was more limited. Mechanistic investigations suggested that \u03b1\u2010arylation occurs through C\u2212H activation\/oxidative addition\/reductive elimination whereas \u03b2\u2010arylation involves desaturation and aryl insertion.\n                  <\/jats:p>","DOI":"10.1002\/chem.202103467","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T08:03:11Z","timestamp":1636617791000},"page":"17688-17694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Site\u2010Selective Pd\u2010Catalyzed C(sp\n                    <sup>3<\/sup>\n                    )\u2212H Arylation of Heteroaromatic Ketones"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9161-1039","authenticated-orcid":false,"given":"Anton","family":"Kudashev","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Basel  St. Johanns-Ring 19 CH-4056 Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0847-8493","authenticated-orcid":false,"given":"Olivier","family":"Baudoin","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Basel  St. Johanns-Ring 19 CH-4056 Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01627"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm049614v"},{"key":"e_1_2_7_4_1","unstructured":"\u00a0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9605694"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/op025549s"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.46.1672"},{"key":"e_1_2_7_8_1","unstructured":"For examples see:"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo101821r"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202012103"},{"key":"e_1_2_7_10_3","first-page":"60","year":"2021","journal-title":"Angew. Chem."},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC03456A"},{"key":"e_1_2_7_12_1","unstructured":"\u00a0"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00064B"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c04074"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC05944G"},{"key":"e_1_2_7_16_1","unstructured":"\u00a0"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b05978"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201801445"},{"key":"e_1_2_7_18_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201801445"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-019-0245-6"},{"key":"e_1_2_7_20_1","unstructured":"\u00a0"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol1000318"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.05.032"},{"key":"e_1_2_7_23_1","unstructured":"\u00a0"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol051255q"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201611407"},{"key":"e_1_2_7_25_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201611407"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202000306"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b00923"},{"key":"e_1_2_7_28_1","unstructured":"For related processes see:"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201208627"},{"key":"e_1_2_7_29_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201208627"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201300833"},{"key":"e_1_2_7_30_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201300833"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00169"},{"key":"e_1_2_7_32_1","unstructured":"\u00a0"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja410389a"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC01636C"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201700277"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2018.03.017"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c01519"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00099"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.2016.768"},{"key":"e_1_2_7_40_1","unstructured":"\u00a0"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo400159y"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00622"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00621"},{"key":"e_1_2_7_44_1","unstructured":"\u00a0"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b04966"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b01359"},{"key":"e_1_2_7_47_1","unstructured":"\u00a0"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1246\/cl.2010.1118"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr900315k"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr100412j"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00839"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c01798"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201403213"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja055819x"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202103467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.202103467","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202103467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:13:23Z","timestamp":1760285603000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202103467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,11]]},"references-count":59,"journal-issue":{"issue":"70","published-print":{"date-parts":[[2021,12,15]]}},"alternative-id":["10.1002\/chem.202103467"],"URL":"https:\/\/doi.org\/10.1002\/chem.202103467","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,11]]},"assertion":[{"value":"2021-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}