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We have been able to develop a simple strategy in a sequence of two unprecedented steps combining a diastereoselective aldol\u2010Tishchenko reaction and an enantioselective organocatalyzed kinetic resolution. The aldol\u2010Tishchenko reaction directly generates a large panel of acyclic 1,3\u2010diols possessing a fluorinated tetrasubstituted stereocenter by condensation of fluorinated ketones with aldehydes under very mild basic conditions. The <jats:italic>anti<\/jats:italic> 1,3\u2010diols featuring three contiguous stereogenic centers are generated with excellent diastereocontrol (typically &gt;99\u2009:\u20091 <jats:italic>dr<\/jats:italic>). Depending upon the precursors both diastereomers of stereotriads are accessible through this flexible reaction. Furthermore, from the obtained racemic scaffolds, development of an organocatalyzed kinetic resolution enabled to generate the desired enantioenriched stereotriads with excellent selectivity (typically er &gt;95\u2009:\u20095).<\/jats:p>","DOI":"10.1002\/chem.202103874","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T11:37:33Z","timestamp":1637840253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Enantioselective Synthesis of Acyclic Stereotriads Featuring Fluorinated Tetrasubstituted Stereocenters"],"prefix":"10.1002","volume":"28","author":[{"given":"Na","family":"Shao","sequence":"first","affiliation":[{"name":"Aix Marseille Univ CNRS Centrale Marseille iSm2  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ CNRS Centrale Marseille iSm2  Marseille 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