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Key elements of the strategy include a pivotal aldol reaction which led to bond formation between the C24\u2010C40 and the C8\u2010C23 fragment. The remaining C1\u2010C7 fragment was attached by a Yamaguchi esterification completing the assembly of the 40 carbon atoms within the main skeleton. Ring closure to the 22\u2010membered lactone ring was achieved in the final stages of the synthesis by a Heck reaction. 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