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The reaction features in situ protection and activation of an \u03b1,\u03b2\u2010unsaturated carboxylic acid by a hydrosilane. The copper enolate formed in situ reacts with an alkyl aryl ketone to afford the \u03b2\u2010hydroxy carboxylic acid with excellent enantioselectivity (up to 99\u2009% <jats:italic>ee<\/jats:italic>). The corresponding gram\u2010scale reaction with a low catalyst loading and the derivatization of the \u03b2\u2010hydroxy carboxylic acids highlight the practicality of this transformation.<\/jats:p>","DOI":"10.1002\/chem.202104273","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T10:01:04Z","timestamp":1640858464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Copper\u2010Catalyzed Enantioselective Reductive Aldol Reaction of \u03b1,\u03b2\u2010Unsaturated Carboxylic Acids to Alkyl Aryl Ketones: Silanes as Activator and Transient Protecting Group"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0252-7688","authenticated-orcid":false,"given":"Hirotsugu","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry Tokyo University of Science  1\u20133 Kagurazaka Shinjuku-ku Tokyo 162-8601 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9783527693931","volume-title":"Bioactive Carboxylic Compound Classes: Pharmaceuticals and Agrochemicals","author":"Lamberth 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