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Benefiting from the \u03c0\u2010d delocalization e\ufb00ect of electrons, excellent metal\u2010chelating property, high electron transferability, and good chemical stability of \u03c0\u2010conjugated phthalocyanine, the design of the copper phthalocyanine\u2010based conjugated polymer nanoparticles (Cu\u2010PcCP NPs) as a colorimetric sensor for a variety of biomarkers is reported. The Cu\u2010PcCP NPs are synthesized through a simple microwave\u2010assisted polymerization, and their chemical structures are thoroughly characterized. The colorimetric results of Cu\u2010PcCP NPs demonstrate excellent peroxidase\u2010like detecting activity and also great substrate selectivity than most of the reported Cu\u2010based nanomaterials. 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