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It therefore is essential to be able to perform in\u2005vivo and ex vivo reference measurements with the natural patellamide macrocycles, very similar derivatives and a large range of synthetic analogues. The preparative method described allows for a highly adaptable synthetic process producing building blocks for a large range of patellamide derivatives: apart from natural compounds, a new synthetic patellamide was prepared that does not have any substituents at any of the four heterocycles. Together with the variation of substituents at the aliphatic backbone, this allowed to elucidate the catalytic activity for phosphoester hydrolysis as a function of the structure and dynamics of the dicopper(II)\u2010patellamide complexes, both by experiment and DFT\u2010based mechanistic studies.<\/jats:p>","DOI":"10.1002\/chem.202200249","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T06:14:20Z","timestamp":1645164860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficient Synthesis for a Wide Variety of Patellamide Derivatives and Phosphatase Activity of Copper\u2010Patellamide Complexes"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0701-6756","authenticated-orcid":false,"given":"Philipp","family":"Baur","sequence":"first","affiliation":[{"name":"Universit\u00e4t Heidelberg Anorganisch-Chemisches Institut und Interdisziplin\u00e4res Zentrum f\u00fcr Wissenschaftliches Rechnen  Im Neuenheimer Feld 270 69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7796-3532","authenticated-orcid":false,"given":"Peter","family":"Comba","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Heidelberg Anorganisch-Chemisches Institut und Interdisziplin\u00e4res Zentrum f\u00fcr Wissenschaftliches Rechnen  Im Neuenheimer Feld 270 69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3244-2690","authenticated-orcid":false,"given":"Gunasekaran","family":"Velmurugan","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Heidelberg Anorganisch-Chemisches Institut und Interdisziplin\u00e4res Zentrum f\u00fcr Wissenschaftliches Rechnen  Im Neuenheimer Feld 270 69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00349a002"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201101975"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3DT52664J"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201700895"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-319-59100-1_2","volume-title":"Future Directions in Metalloprotein and Metalloenzyme Research\u201d, Biological Magnetic Resonance, Vol 3","author":"Comba P.","year":"2017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/md20020119"},{"key":"e_1_2_8_7_1","first-page":"140","author":"Jaspers M.","year":"2000","journal-title":"RSC Special Publ."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501424102"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00402"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3DT53135J"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic5014413"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)91572-7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)98890-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2018.06.030"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201701659"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol801895y"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200300207"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic2004694"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo0302657"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200390059"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200390029"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)71841-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1990-21115"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1996-5564"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1992-21299"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)81482-4"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1995-4993"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc34836e"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6DT03787A"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2016.02.014"},{"key":"e_1_2_8_30_1","volume-title":"Essentials of Organic Chemistry: For Students of Pharmacy, Medicinal Chemistry and Biological Chemistry","author":"Dewick P. 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