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Both bear an alkyne functionality allowing their use in numerous biological applications. They were successfully incorporated in oligonucleotides via solid\u2010phase synthesis. Copper\u2010catalyzed alkyne\u2010azide cycloaddition (CuAAC) using a bisazide photo\u2010tether gave cyclic oligonucleotides that could be relinearized by activation with green light and were shown to exhibit high stability against exonucleases. Chemical ligation as another example for bioconjugation yielded oligonucleotides with an internal strand break site. Irradiation at 530\u2005nm or 565\u2005nm resulted in complete photolysis of both caging groups.<\/jats:p>","DOI":"10.1002\/chem.202200477","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T07:44:40Z","timestamp":1649922280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Green\u2010Light Activatable BODIPY and Coumarin 5\u2019\u2010Caps for Oligonucleotide Photocaging"],"prefix":"10.1002","volume":"28","author":[{"given":"Janik","family":"Kaufmann","sequence":"first","affiliation":[{"name":"Institute for Organic Chemistry and Chemical Biology Goethe University Frankfurt  Max-von-Laue-Str. 7 60438 Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute for Organic Chemistry and Chemical Biology Goethe University Frankfurt  Max-von-Laue-Str. 7 60438 Frankfurt 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