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Crystallographic structures of two key sequences and <jats:sup>1<\/jats:sup>H NMR data in water concur to show that a canonical aromatic helix fold prevails in almost all cases and that helix stability critically depends on the ratio between rigid and flexible units. Notwithstanding subtle variations of curvature, i.\u2009e. the numbers of units per turn, the aromatic \u03b4\u2010peptide helix is therefore shown to be general and tolerant of a great number of sp<jats:sup>3<\/jats:sup> centers. We also demonstrate canonical helical folding upon alternating two monomers that do not promote folding when taken separately: folding occurs with two methylenes between every other unit, not with one methylene between every unit. These findings highlight that a fine\u2010tuning of helix handedness inversion kinetics, curvature, and side chain positioning in aromatic \u03b4\u2010peptidic foldamers can be realized by systematically combining different yet compatible \u03b4\u2010amino acids.<\/jats:p>","DOI":"10.1002\/chem.202200538","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T06:52:57Z","timestamp":1648191177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Generalizing the Aromatic \u03b4\u2010Amino Acid Foldamer Helix"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2878-7592","authenticated-orcid":false,"given":"Daniel","family":"Bindl","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Center for Integrated Protein Science Ludwig-Maximilians-Universit\u00e4t  Butenandtstra\u00dfe 5\u201313 M\u00fcnchen 81377 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