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Here, the four\u2010component Ugi reaction is introduced for the general and precise optical chirality sensing of amines as well as the surface nanoengineering of chiral soft self\u2010assemblies. To overcome the relatively weak Cotton effects, direct synthesis of a folded peptide structure on a rotatable ferrocene core with axial chirality was accomplished from chiral amine, 1,1\u2019\u2010ferrocenyl dicarboxylic acid, formaldehyde and isocyanide. Enhanced Cotton effects benefiting from the folded structure allow for the precise and quantitative sensing of natural and synthetic chiral amines covering alkyl, aromatic amines and amino acid derivatives. In addition, aqueous reaction enables the modification of amine\u2010bearing dye to microfibers self\u2010assembled from \u03c0\u2010conjugated amino acids. Surface dye\u2010modification via Ugi reaction barely changes the pristine morphology, showing non\u2010invasive properties in contrast to dye staining, which is applicable in soft nano\/microarchitectures from self\u2010assembly. This work which combines the four\u2010component Ugi reaction to enable precise ee% detection and surface nanoengineering of soft chiral assemblies sheds light on the advanced application of green chemistry to chirality science.<\/jats:p>","DOI":"10.1002\/chem.202200682","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T06:29:58Z","timestamp":1649744998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Four\u2010Component Ugi Reaction for Optical Chirality Sensing and Surface Nanoengineering of Chiral Self\u2010Assemblies"],"prefix":"10.1002","volume":"28","author":[{"given":"Bingyu","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Colloid and Interface Chemistry of Ministry of Education and School of Chemistry and Chemical Engineering Shandong University  Jinan 250100 P. R. 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