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The image depicts an Ir\u2010based catalytic system \u201cfueled\u201d by hydrogen for the direct reductive amination of ketones and secondary amines, allowing complex aliphatic tertiary amines to be prepared and, so, new chemical space to be reached. Read the full text of the article at<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/doi.org\/10.1002\/chem.202201078\">10.1002\/chem.202201078<\/jats:ext-link>.<\/jats:p>","DOI":"10.1002\/chem.202201592","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T08:19:36Z","timestamp":1654762776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Iridium\u2010Catalyzed Direct Reductive Amination of Ketones and Secondary Amines: Breaking the Aliphatic Wall"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4478-2502","authenticated-orcid":false,"given":"Matthieu","family":"Jouffroy","sequence":"first","affiliation":[{"name":"Chemical Process R&amp;D, Discovery Process Research Janssen Pharmaceutica N.V.  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