{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:15:12Z","timestamp":1776773712715,"version":"3.51.2"},"reference-count":51,"publisher":"Wiley","issue":"67","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ21B020001"],"award-info":[{"award-number":["LZ21B020001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21472170"],"award-info":[{"award-number":["21472170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFE0102200"],"award-info":[{"award-number":["2017YFE0102200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dual\u2010state emission (DSE) luminophores exhibit strong emissions in both solution and solid states, filling the gaps between aggregation\u2010induced emissions (AIE) and aggregation\u2010caused quenching (ACQ). However, limited design concepts and complicated synthetic strategies restrict the discovery of novel DSE molecules. Developing efficient and green methodologies to access novel DSE scaffolds via rational design remains highly desirable. In this work, we report a water\u2010promoted Pd\u2010catalyzed cascade reaction for the synthesis of multi\u2010substituted imidazo[1,2\u2010<jats:italic>a<\/jats:italic>]pyridazine derivatives with DSE properties. The intramolecular interactions of the neighboring benzene rings restrict molecular motion, leading to emissions in the solid state (quantum yield: 11\u2009%), and the newly constructed core structure of imidazo[1,2\u2010<jats:italic>a<\/jats:italic>]pyridazine ensures considerable planarity, allowing for emissions in solution. Further removal of the neighboring phenyl groups resulted in ACQgens, while additional methyl groups led to AIEgens. Subsequent live cell imaging investigations suggested that the novel DSEgens could serve as specific lipid droplet (LD) probes in a wide concentration range.<\/jats:p>","DOI":"10.1002\/chem.202202179","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T10:28:44Z","timestamp":1662460124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Palladium\u2010Catalyzed Cascade Reaction in Water to Imidazo[1,2\u2010<i>a<\/i>]pyridazines as Switchable DSEgens, AIEgens, and ACQgens**"],"prefix":"10.1002","volume":"28","author":[{"given":"Jiaxin","family":"Lao","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences Zhejiang University  Hangzhou 310058 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbiao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Zhejiang University  Hangzhou 310058 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6784-2737","authenticated-orcid":false,"given":"Hongbin","family":"Zou","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Zhejiang University  Hangzhou 310058 P. R. China"},{"name":"Jinhua Institute of Zhejiang University  Jinhua 321000 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","first-page":"143","author":"Li K.","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202000845"},{"key":"e_1_2_8_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202000845"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800711"},{"key":"e_1_2_8_5_1","unstructured":"\u00a0"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00263"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja960145z"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200700098"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/b105159h"},{"key":"e_1_2_8_10_1","unstructured":"\u00a0"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol4005036"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/C3CC49680E"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2201"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201802201"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201804074"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.1c02460"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201501981"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201906507"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201906507"},{"key":"e_1_2_8_19_1","first-page":"2156","volume":"3","author":"Liu Y.","year":"2021","journal-title":"CCS Chem."},{"key":"e_1_2_8_20_1","unstructured":"\u00a0"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c01413"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1GC01572A"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b00875"},{"key":"e_1_2_8_24_1","unstructured":"\u00a0"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1039\/b902802a"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201700169"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2020.12.031"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201808665"},{"key":"e_1_2_8_28_3","first-page":"130","year":"2018","journal-title":"Angew. Chem."},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC07289C"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006191"},{"key":"e_1_2_8_30_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202006191"},{"key":"e_1_2_8_31_1","unstructured":"\u00a0"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b00150"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201103329"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b02845"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC01035A"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5GC01008J"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC06000C"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202101109"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2021.05.018"},{"key":"e_1_2_8_40_1","unstructured":"\u00a0"},{"key":"e_1_2_8_41_2","first-page":"13","volume":"35","author":"Kayagil I.","year":"2011","journal-title":"Turk. J. Chem."},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.11.007"},{"key":"e_1_2_8_43_1","unstructured":"\u00a0"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0QO01244K"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo060220g"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201913249"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201913249"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202202179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.202202179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202202179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T22:14:55Z","timestamp":1760307295000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202202179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,13]]},"references-count":51,"journal-issue":{"issue":"67","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/chem.202202179"],"URL":"https:\/\/doi.org\/10.1002\/chem.202202179","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,13]]},"assertion":[{"value":"2022-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202202179"}}