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The resulting ketenimines are trapped in\u2005situ with various bisnucleophiles to access a range of densely functionalized heterocycles (pyrimidinones, dihydropyrazolones, 1<jats:italic>H<\/jats:italic>\u2010tetrazoles) in a one\u2010pot process. The electron\u2010rich Hieber anion ([Fe(CO)<jats:sub>3<\/jats:sub>NO]<jats:sup>\u2212<\/jats:sup>) facilitates efficient catalytic carbene transfer from acceptor\u2010type \u03b1\u2010diazo carbonyl compounds to isocyanides, providing a cost\u2010efficient and benign alternative to similar noble metal\u2010catalysed processes. Based on DFT calculations a plausible reaction mechanism for activation of the \u03b1\u2010diazo carbonyl carbene precursor and ketenimine formation is provided.<\/jats:p>","DOI":"10.1002\/chem.202203074","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T05:41:46Z","timestamp":1666935706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Iron\u2010Catalysed Carbene Transfer to Isocyanides as a Platform for Heterocycle Synthesis"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4567-1302","authenticated-orcid":false,"given":"Thomas R.","family":"Roose","sequence":"first","affiliation":[{"name":"Department of Chemistry &amp; Pharmaceutical Sciences Amsterdam Institute for Molecular &amp; Life Sciences Vrije Universiteit Amsterdam  De Boelelaan 1108 1081 HZ Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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