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Discovery of a mild base mediated process allows radio\u2010iodination in HFIP (1,1,1,3,3,3\u2010hexafluoro\u20102\u2010propanol) of either aryl silane or germane, with germanes being more reactive. Clinical potential of arylgermanes as radio\u2010iodination precursors is demonstrated through the labelling of <jats:bold>[<jats:sup>125<\/jats:sup>I]IMTO<\/jats:bold> (iodometomidate) and <jats:bold>[<jats:sup>125<\/jats:sup>I]MIBG<\/jats:bold> (<jats:italic>meta<\/jats:italic>\u2010iodobenzylguanidine) thus offering an alternative to radio\u2010iododestannylation processes using non\u2010toxic precursors.<\/jats:p>","DOI":"10.1002\/chem.202203366","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T09:35:12Z","timestamp":1672997712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Base\u2010Mediated Radio\u2010Iodination of Arenes by Using Organosilane and Organogermane as Radiolabelling Precursors"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4209-4979","authenticated-orcid":false,"given":"Hugo","family":"Bloux","sequence":"first","affiliation":[{"name":"Centre d'Etudes et de Recherche sur le M\u00e9dicament de Normandie (CERMN) Normandie Univ, UNICAEN  14000 Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Dahiya","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry RWTH Aachen University  Landoltweg 1 52074 Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"H\u00e9bert","sequence":"additional","affiliation":[{"name":"Centre d'Etudes et de Recherche sur le M\u00e9dicament de Normandie (CERMN) Normandie Univ, UNICAEN  14000 Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8507-4073","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Fabis","sequence":"additional","affiliation":[{"name":"Centre d'Etudes et de Recherche sur le M\u00e9dicament de Normandie (CERMN) Normandie Univ, UNICAEN  14000 Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-0929","authenticated-orcid":false,"given":"Franziska","family":"Schoenebeck","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry RWTH Aachen University  Landoltweg 1 52074 Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5262-4494","authenticated-orcid":false,"given":"Thomas","family":"Cailly","sequence":"additional","affiliation":[{"name":"Centre d'Etudes et de Recherche sur le M\u00e9dicament de Normandie (CERMN) Normandie Univ, UNICAEN  14000 Caen France"},{"name":"IMOGERE Normandie Univ, UNICAEN  14000 Caen France"},{"name":"Department of Nuclear Medicine CHU C\u00f4te de Nacre  14000 Caen France"},{"name":"Institut Blood and Brain @Caen-Normandie (BB@C)  Boulevard Henri Becquerel 14074 Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/b313872k"},{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"N.\u2005S.Mason C.\u2005A. 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