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Owing to the slow activation of the pronucleophile by the weak Br\u00f8nsted base, the \u03b1\u2010functionalization of ketones with tertiary\u2010amine\u2010derived Br\u00f8nsted base catalysis has been chemically challenging in asymmetric transformations. Herein, we demonstrate that the cinchona\u2010derived squaramide catalyst works effectively for the intramolecular Michael addition of cyclobutanone to enones and affords the architecturally fascinating [6,5,4]\u2010fused carbocyclic skeleton in good yields and excellent diastereo\u2010 and enantioselectivities (up to &gt;20\u2009:\u20091 <jats:italic>dr<\/jats:italic> and 96\u2009% <jats:italic>ee<\/jats:italic>). Furthermore, as a synthetic application, this method provides an alternative pathway to enantioenriched high\u2010value products like \u03b3\u2010lactones and indan\u20102\u2010ol derivatives.<\/jats:p>","DOI":"10.1002\/chem.202203407","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T02:04:02Z","timestamp":1674612242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Organocatalytic Desymmetric Conjugate Addition to Cyclobutanone: An Enantio\u2010 and Diastereoselective Synthesis of [6,5,4]\u2010Fused Carbocycles"],"prefix":"10.1002","volume":"29","author":[{"given":"Shibaram","family":"Panda","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Science Education and Research (IISER) Bhopal  Bhopal By-pass Road, Bhauri Bhopal 462066 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