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While this\n                    <jats:italic>in\u2010flow<\/jats:italic>\n                    effect is tolerable for high sensitivity nuclei such as\n                    <jats:sup>1<\/jats:sup>\n                    H and\n                    <jats:sup>19<\/jats:sup>\n                    F, it significantly reduces the signal\u2010to\u2010noise ratio in\n                    <jats:sup>31<\/jats:sup>\n                    P and\n                    <jats:sup>13<\/jats:sup>\n                    C spectra, making FlowNMR impractical for low sensititvity nuclei at low concentrations. Paramagnetic relaxation agents (PRAs), which enhance polarisation and spin\u2010lattice relaxation, could eliminate the adverse\n                    <jats:italic>in\u2010flow<\/jats:italic>\n                    effect and improve the signal\u2010to\u2010noise ratio. Herein, [Co(acac)\n                    <jats:sub>3<\/jats:sub>\n                    ], [Mn(acac)\n                    <jats:sub>3<\/jats:sub>\n                    ], [Fe(acac)\n                    <jats:sub>3<\/jats:sub>\n                    ]\n                    <jats:sub>,<\/jats:sub>\n                    [Cr(acac)\n                    <jats:sub>3<\/jats:sub>\n                    ]\n                    <jats:sub>,<\/jats:sub>\n                    [Ni(acac)\n                    <jats:sub>2<\/jats:sub>\n                    ]\n                    <jats:sub>3,<\/jats:sub>\n                    [Gd(tmhd)\n                    <jats:sub>3<\/jats:sub>\n                    ] and [Cr(tmhd)\n                    <jats:sub>3<\/jats:sub>\n                    ] are investigated for their effectiveness in improving signal intensity per unit time in FlowNMR applications under the additional constraint of chemical inertness towards catalytically active transition metal complexes. High\u2010spin Cr(III) acetylacetonates emerged as the most effective compounds, successfully reducing\n                    <jats:sup>31<\/jats:sup>\n                    P T\n                    <jats:sub>1<\/jats:sub>\n                    values four\u2010 to five\u2010fold at PRA concentrations as low as 10\u2005mM without causing adverse line broadening. Whereas [Cr(acac)\n                    <jats:sub>3<\/jats:sub>\n                    ] showed signs of chemical reactivity with a mixture of triphenylphosphine, triphenylphosphine oxide and triphenylphosphate over the course of several hours at 80\u00b0 C, the bulkier [Cr(tmhd)\n                    <jats:sub>3<\/jats:sub>\n                    ] was stable and equally effective as a PRA under these conditions. Compatibility with a range of representative transition metal complexes often used in homogeneous catalysis has been investigated, and application of [Cr(tmhd)\n                    <jats:sub>3<\/jats:sub>\n                    ] in significantly improving\n                    <jats:sup>1<\/jats:sup>\n                    H and\n                    <jats:sup>31<\/jats:sup>\n                    P{\n                    <jats:sup>1<\/jats:sup>\n                    H} FlowNMR data quality in a Rh\u2010catalysed hydroformylation reaction has been demonstrated. With the PRA added,\n                    <jats:sup>13<\/jats:sup>\n                    C relaxation times were reduced more than six\u2010fold, allowing quantitative reaction monitoring of substrate consumption and product formation by\n                    <jats:sup>13<\/jats:sup>\n                    C{\n                    <jats:sup>1<\/jats:sup>\n                    H} FlowNMR spectroscopy at natural abundance.\n                  <\/jats:p>","DOI":"10.1002\/chem.202300215","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T08:14:55Z","timestamp":1679472895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Paramagnetic Relaxation Agents for Enhancing Temporal Resolution and Sensitivity in Multinuclear FlowNMR Spectroscopy"],"prefix":"10.1002","volume":"29","author":[{"given":"Alejandro","family":"Bara\u2010Esta\u00fan","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Bath Claverton Down  Bath BA2 7AY United Kingdom"},{"name":"Dynamic Reaction Monitoring Facility University of Bath, Claverton Down  Bath BA2 7AY United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie C.","family":"Harder","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Bath Claverton Down  Bath BA2 7AY United Kingdom"},{"name":"Dynamic Reaction Monitoring Facility University of Bath, Claverton Down  Bath BA2 7AY United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine L.","family":"Lyall","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Bath Claverton Down  Bath BA2 7AY United Kingdom"},{"name":"Dynamic Reaction Monitoring Facility University of Bath, Claverton Down  Bath BA2 7AY United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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