{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:59:22Z","timestamp":1780477162384,"version":"3.54.1"},"reference-count":85,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["883212"],"award-info":[{"award-number":["883212"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2023,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of stereogenic\u2010at\u2010metal iron complexes comprising a non\u2010<jats:italic>C<\/jats:italic><jats:sub>2<\/jats:sub>\u2010symmetric chiral topology is introduced and applied to asymmetric 3d\u2010transition metal catalysis. The chiral iron(II) complexes are built from chiral tetradentate N4\u2010ligands containing a proline\u2010derived amino pyrrolidinyl backbone which controls the relative (<jats:italic>cis<\/jats:italic>\u2010\u03b1 coordination) and absolute metal\u2010centered configuration (\u039b vs. \u0394). Two chloride ligands complement the octahedral coordination sphere. The modular composition of the tetradentate ligands facilitates the straightforward incorporation of different terminal coordinating heteroaromatic groups into the scaffold. The influence of various combinations was evaluated in an asymmetric ring contraction of isoxazoles to 2<jats:italic>H<\/jats:italic>\u2010azirines revealing that a decrease of symmetry is beneficial for the stereoinduction to obtain chiral products in up to 99\u2009% yield and with up to 92\u2009%\u2009<jats:italic>ee<\/jats:italic>. Conveniently, iron catalysis is feasible under open flask conditions with the bench\u2010stable dichloro complexes exhibiting high robustness towards oxidative or hydrolytic decomposition. The versatility of non\u2010racemic 2<jats:italic>H<\/jats:italic>\u2010azirines was subsequently showcased with the conversion into a variety of quaternary \u03b1\u2010amino acid derivatives.<\/jats:p>","DOI":"10.1002\/chem.202300267","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T17:16:35Z","timestamp":1682615795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Trading Symmetry for Stereoinduction in Tetradentate, non\u2010<i>C<\/i><sub>2<\/sub>\u2010Symmetric Fe(II)\u2010Complexes for Asymmetric Catalysis"],"prefix":"10.1002","volume":"29","author":[{"given":"Philipp S.","family":"Steinlandt","sequence":"first","affiliation":[{"name":"Fachbereich Chemie Philipps-Universit\u00e4t Marburg  Hans-Meerwein-Strasse 4 35043 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Hemming","sequence":"additional","affiliation":[{"name":"Fachbereich Chemie Philipps-Universit\u00e4t Marburg  Hans-Meerwein-Strasse 4 35043 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulan","family":"Xie","sequence":"additional","affiliation":[{"name":"Fachbereich Chemie Philipps-Universit\u00e4t Marburg  Hans-Meerwein-Strasse 4 35043 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei I.","family":"Ivlev","sequence":"additional","affiliation":[{"name":"Fachbereich Chemie Philipps-Universit\u00e4t Marburg  Hans-Meerwein-Strasse 4 35043 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8851-7623","authenticated-orcid":false,"given":"Eric","family":"Meggers","sequence":"additional","affiliation":[{"name":"Fachbereich Chemie Philipps-Universit\u00e4t Marburg  Hans-Meerwein-Strasse 4 35043 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"P.\u2005J. 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