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Although the molecular size of the PEGylated porphyrin is much greater than that of the CD dimer, the sandwich\u2010type porphyrin\/CD dimer 1\u2009:\u20091 inclusion complex was spontaneously formed in water. The ferrous porphyrin complex binds O<jats:sub>2<\/jats:sub> reversibly in aqueous solution, which functions as an artificial O<jats:sub>2<\/jats:sub> carrier in\u2005vivo. Pharmacokinetic study using rats revealed that the inclusion complex showed a long circulation in blood in contrast to the complex without PEG. We further demonstrate the unique host\u2013guest exchange reaction from the PEGylated porphyrin\/CD monomer 1\/2 inclusion complex to the 1\/1 complex with the CD dimer through the complete dissociation process of the CD monomers.<\/jats:p>","DOI":"10.1002\/chem.202300408","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T02:54:17Z","timestamp":1677725657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inclusion Complex Formation with Tetra\u2010PEGylated Tetraphenylporphyrin and Face\u2010to\u2010Face Cyclodextrin Dimer through Unprecedented Molecular Threading"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-5890","authenticated-orcid":false,"given":"Qiyue","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Molecular Chemistry and Biochemistry Faculty of Science and Engineering Doshisha University  1-3 Tatara 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