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Several studies have highlighted that Tf can interact with metals other than Fe(III), including actinides that are chemical and radiological toxics. We propose here to report on the behavior of Th(IV) and Pu(IV) in comparison with Fe(III) upon Tf complexation. We considered UV\u2010Vis and IR data of the M<jats:sub>2<\/jats:sub>Tf complex (M=Fe, Th, Pu) and combined experimental EXAFS data with MD models. EXAFS data of the first M\u2212O coordination sphere are consistent with the MD model considering 1 synergistic carbonate. Further EXAFS data analysis strongly suggests that contamination by Th\/Pu colloids seems to occur upon Tf complexation, but it seems limited. SAXS data have also been recorded for all complexes and also after the addition of Deferoxamine\u2010B (DFOB) in the medium. The Rg values are very close for apoTf, ThTf and PuTf, but slightly larger than for holoTf. Data suggest that the structure of the protein is more ellipsoidal than spherical, with a flattened oblate form. From this data, the following order of conformation size might be considered:holoTf&lt;M<jats:sub>2<\/jats:sub>Tf (M=Th, Pu)&lt;apoTf&lt;M<jats:sub>2<\/jats:sub>Tf\u2010DFOB (M=Fe, Th, Pu).<\/jats:p>","DOI":"10.1002\/chem.202300636","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T06:31:32Z","timestamp":1690871492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interaction Between the Transferrin Protein and Plutonium (and Thorium), What's New?"],"prefix":"10.1002","volume":"29","author":[{"given":"Cyril","family":"Zurita","sequence":"first","affiliation":[{"name":"Universit\u00e9 C\u00f4te d'Azur, CNRS Institut de Chimie de Nice  06108 Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4520-6147","authenticated-orcid":false,"given":"Satoru","family":"Tsushima","sequence":"additional","affiliation":[{"name":"Institute of Resource Ecology Helmholtz-Zentrum Dresden-Rossendorf (HZDR)  01328 Dresden Germany"},{"name":"Internationnal Research Frontiers Initiative, Institute of Innovative Research Tokyo Institute of Technology, Meguro  152-8550 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Lorenzo","family":"Solari","sequence":"additional","affiliation":[{"name":"Synchrotron SOLEIL L'Orme des Merisiers  91190 Saint Aubin France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8657-3333","authenticated-orcid":false,"given":"Denis","family":"Menut","sequence":"additional","affiliation":[{"name":"Synchrotron SOLEIL L'Orme des Merisiers  91190 Saint Aubin France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Dourdain","sequence":"additional","affiliation":[{"name":"ICSM Universit\u00e9 de Montpellier, CEA, CNRS, ENSCM  Marcoule France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Jeanson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d'Azur, CNRS Institut de Chimie de Nice  06108 Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2366-7628","authenticated-orcid":false,"given":"Ga\u00eblle","family":"Creff","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d'Azur, CNRS Institut de Chimie de Nice  06108 Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2880-0280","authenticated-orcid":false,"given":"Christophe","family":"Den Auwer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d'Azur, CNRS Institut de Chimie de Nice  06108 Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"National Council on Radiation Protection and Measurements Management of persons contaminated with radionuclides 2008 1."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr990114x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1524\/ract.1983.32.13.43"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-3598-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-196212000-00015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-8388(98)00034-6"},{"key":"e_1_2_9_7_1","unstructured":"ICRP publication n\u00b056 Age-dependent doses to members of the public from intake of radionuclides. 1. 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