{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:41:05Z","timestamp":1792201265407,"version":"4.4.0"},"reference-count":74,"publisher":"Wiley","issue":"36","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2019-06050"],"award-info":[{"award-number":["RGPIN-2019-06050"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2023,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Stereodivergent dual catalysis has emerged as a powerful tool to selectively prepare all four stereoisomers in molecules containing two chiral centers from common starting materials. Most processes involve the use of two substrates, and it remains challenging to use dual catalyst approaches to generate molecules having three newly formed stereocenters with high diastereo\u2010 and enantioselectivity. Here we report a multicomponent, stereodivergent method for the synthesis of targets containing three contiguous stereocenters by the combination of enantioselective Rh\u2010catalyzed conjugate addition and Ir\u2010catalyzed allylic alkylation methodologies. Both cyclic and acyclic \u03b1,\u03b2\u2010unsaturated ketones undergo \u03b2\u2010arylation using aryl boron reagents to form an enolate nucleophile that can be subsequently allylated at the \u03b1\u2010position. The reactions proceed often with &gt;95\u2009%\u2009ee and with &gt;90\u2009:\u200910\u2005dr. Epimerization at the \u03b1\u2010carbonyl center enables the preparation of any of the eight possible stereoisomers from common starting materials, as demonstrated for cyclohexanone products.<\/jats:p>","DOI":"10.1002\/chem.202300727","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T22:24:25Z","timestamp":1678487065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Combining Enantioselective Rh\u2010Catalyzed Conjugate Addition and Ir\u2010Catalyzed Allylic Alkylation in Stereodivergent, Multicomponent Coupling Reactions to Form Three Stereocenters**"],"prefix":"10.1002","volume":"29","author":[{"given":"Qiqige","family":"Qiqige","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Alberta  T6G\u20092G2 Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-6946","authenticated-orcid":false,"given":"Rylan J.","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta  T6G\u20092G2 Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duanyang","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta  T6G\u20092G2 Edmonton Alberta Canada"},{"name":"State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology  100029 Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr040700c"},{"key":"e_1_2_8_3_2","volume-title":"Comprehensive Chirality","author":"Carreira E. 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