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Here, we report the first ligand\u2010directed H<jats:sub>2<\/jats:sub>S\u2010specific near\u2010infrared fluorescent sensor PSMA\u2010Cy7\u2010NBD and scavenger PSMA\u2010Py\u2010NBD that target the prostate\u2010specific membrane antigen (PSMA). PSMA\u2010Cy7\u2010NBD displays a 53\u2010fold off\u2013on fluorescence response to H<jats:sub>2<\/jats:sub>S at 803\u2005nm with high specificity. PSMA\u2010Py\u2010NBD can scavenge H<jats:sub>2<\/jats:sub>S fast (<jats:italic>k<\/jats:italic><jats:sub>2<\/jats:sub>=30.8\u2005M<jats:sup>\u22121<\/jats:sup>\u2009s<jats:sup>\u22121<\/jats:sup> at 25\u2009\u00b0C) without interference from biothiols. Both tools are highly water\u2010soluble and can be transported selectively into PSMA\u2010expressing prostate cancer cells. Endogenous H<jats:sub>2<\/jats:sub>S levels in murine 22Rv1 tumor models can be imaged and downregulated by intravenous injection of PSMA\u2010Cy7\u2010NBD and PSMA\u2010Py\u2010NBD, respectively. These tools could potentially help to investigate H<jats:sub>2<\/jats:sub>S cancer biology and with related therapies.<\/jats:p>","DOI":"10.1002\/chem.202301105","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T09:30:00Z","timestamp":1685179800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ligand\u2010Directed H<sub>2<\/sub>S Probe and Scavenger for Specific Tumor Imaging"],"prefix":"10.1002","volume":"29","author":[{"given":"Xuekang","family":"Cai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organic-Inorganic Composites Beijing Key Lab of Bioprocess Beijing University of Chemical Technology  15 Beisanhuan East Road Beijing 100029 P. R. China"},{"name":"Department of Nuclear Medicine Peking University First Hospital  8 Xishiku Street Beijing 100034 P. R. 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