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However, their use has been somehow limited given the emergence of bacteria with resistance mechanisms, such as \u03b2\u2010lactamases, which inactivate them by degrading their four\u2010membered \u03b2\u2010lactam rings. So, a total knowledge of the mechanisms governing the catalytic activity of \u03b2\u2010lactamases is required. Here, we report a novel Zn\u2010based metal\u2013organic framework (MOF, <jats:bold>1<\/jats:bold>), possessing functional channels capable to accommodate and interact with antibiotics, which catalyze the selective hydrolysis of the penicillinic antibiotics amoxicillin and ceftriaxone. In particular, MOF <jats:bold>1<\/jats:bold> degrades, very efficiently, the four\u2010membered \u03b2\u2010lactam ring of amoxicillin, acting as a \u03b2\u2010lactamase mimic, and expands the very limited number of MOFs capable to mimic catalytic enzymatic processes. Combined single\u2010crystal X\u2010ray diffraction (SCXRD) studies and density functional (DFT) calculations offer unique snapshots on the host\u2010guest interactions established between amoxicillin and the functional channels of <jats:bold>1<\/jats:bold>. This allows to propose a degradation mechanism based on the activation of a water molecule, promoted by a Zn\u2010bridging hydroxyl group, concertedly to the nucleophilic attack to the carbonyl moiety and the cleaving of C\u2212N bond of the lactam ring.<\/jats:p>","DOI":"10.1002\/chem.202301325","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T08:33:20Z","timestamp":1686126800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Degradation of Penicillinic Antibiotics and \u03b2\u2010Lactamase Enzymatic Catalysis in a Biomimetic Zn\u2010Based Metal\u2013Organic Framework"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-8891","authenticated-orcid":false,"given":"Paula","family":"Escamilla","sequence":"first","affiliation":[{"name":"Instituto de Ciencia Molecular (ICMOL) Universitat deVal\u00e8ncia Paterna  46980 Val\u00e8ncia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Bartella","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie Chimiche Universit\u00e0 della Calabria  87030 Rende Cosenza Italy"},{"name":"QUASIORA Laboratory AGRINFRA Research Net Universit\u00e0 della Calabria  87036 Rende Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Sanz\u2010Navarro","sequence":"additional","affiliation":[{"name":"Instituto de Tecnolog\u00eda Qu\u00edmica Universidad Polit\u00e8cnica de Val\u00e8ncia-Consejo Superior de Investigaciones Cient\u00edficas (UPV-CSIC)  46022 Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita Maria","family":"Percoco","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie Chimiche Universit\u00e0 della Calabria  87030 Rende Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Di Donna","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie Chimiche Universit\u00e0 della Calabria  87030 Rende Cosenza Italy"},{"name":"QUASIORA Laboratory AGRINFRA Research Net Universit\u00e0 della Calabria  87036 Rende Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Prejan\u00f2","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie Chimiche Universit\u00e0 della Calabria  87030 Rende Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Marino","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie Chimiche Universit\u00e0 della Calabria  87030 Rende Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Ferrando\u2010Soria","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia Molecular (ICMOL) Universitat deVal\u00e8ncia Paterna  46980 Val\u00e8ncia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8502-8074","authenticated-orcid":false,"given":"Donatella","family":"Armentano","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie Chimiche Universit\u00e0 della Calabria  87030 Rende Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Leyva\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Instituto de Tecnolog\u00eda Qu\u00edmica Universidad Polit\u00e8cnica de Val\u00e8ncia-Consejo Superior de Investigaciones Cient\u00edficas (UPV-CSIC)  46022 Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1394-2553","authenticated-orcid":false,"given":"Emilio","family":"Pardo","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia Molecular (ICMOL) Universitat deVal\u00e8ncia Paterna  46980 Val\u00e8ncia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"1","volume-title":"Burger's Med. 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