{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:34:05Z","timestamp":1788816845164,"version":"build-2803163510"},"reference-count":113,"publisher":"Wiley","issue":"43","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004215"],"award-info":[{"award-number":["82004215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003624"],"award-info":[{"award-number":["82003624"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82141203"],"award-info":[{"award-number":["82141203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004003,"],"award-info":[{"award-number":["82004003,"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["20YF1458700"],"award-info":[{"award-number":["20YF1458700"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["ZYYCXTDD-202004"],"award-info":[{"award-number":["ZYYCXTDD-202004"]}],"id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010Amino sulfones are commonly found structural motifs in biologically active compounds. Herein, we report a direct photocatalyzed amino\u2010sulfonylation reaction of alkenes for the efficicient production of important compounds by simple hydrolysis without the need for additional oxidants and reductants. In this transformation, the sulfonamides worked as bifunctional reagents, simultaneously generating sulfonyl radicals and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010centered radicals which were added to alkene in a highly atom\u2010economical fashion with high regioselectivity and diastereoselectivity. This approach showed high functional group tolerance and compatibility, facilitating the late\u2010stage modification of some bioactive alkenes and sulfonamide molecules, thereby expanding the biologically relevant chemical space. Scaling up this reaction led to an efficient green synthesis of apremilast, one of the best\u2010selling pharmceuticals, demonstrating the synthetic utility of the applied method. Moreover, mechanistic investigations suggest that an energy transfer (EnT) process was in operation.\n                  <\/jats:p>","DOI":"10.1002\/chem.202301392","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T03:20:34Z","timestamp":1684812034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["EnT\u2010Mediated Amino\u2010Sulfonylation of Alkenes with Bifunctional Sulfonamides: Access to\n                    <i>\u03b2<\/i>\n                    \u2010Amino Sulfone Derivatives"],"prefix":"10.1002","volume":"29","author":[{"given":"Ji\u2010Wei","family":"Sang","sequence":"first","affiliation":[{"name":"Department of Phytochemistry, School of Pharmacy Second Military Medical University  Shanghai 200433 China"},{"name":"Department School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang, Henan 453007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Phytochemistry, School of Pharmacy Second Military Medical University  Shanghai 200433 China"},{"name":"Department School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang, Henan 453007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingding","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Phytochemistry, School of Pharmacy Second Military Medical University  Shanghai 200433 China"},{"name":"Department School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang, Henan 453007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200  Cailun Road Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9561-7633","authenticated-orcid":false,"given":"Jinxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Phytochemistry, School of Pharmacy Second Military Medical University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Phytochemistry, School of Pharmacy Second Military Medical University  Shanghai 200433 China"},{"name":"Department School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang, Henan 453007 China"},{"name":"Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200  Cailun Road Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0021-z"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0805"},{"key":"e_1_2_8_3_1","unstructured":"\u00a0"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0103920"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm900210d"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00557-1"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70276-X"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1358\/dof.1989.014.12.109647"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/14756368609020108"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)88273-8"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/md20020109"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.01.045"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.1c00107"},{"key":"e_1_2_8_14_1","unstructured":"\u00a0"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo972167p"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(97)00163-4"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19990115)38:1\/2<195::AID-ANIE195>3.0.CO;2-6"},{"key":"e_1_2_8_17_3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3757(19990115)111:1\/2<212::AID-ANGE212>3.0.CO;2-E"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0690(200003)2000:6<879::AID-EJOC879>3.0.CO;2-E"},{"key":"e_1_2_8_19_1","unstructured":"\u00a0"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol060314c"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202207334"},{"key":"e_1_2_8_21_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202207334"},{"key":"e_1_2_8_22_1","unstructured":"\u00a0"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-4166(01)00411-6"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)01423-4"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-4166(98)00225-0"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol034892u"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol053132b"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1ob05992k"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202100350"},{"key":"e_1_2_8_30_1","unstructured":"\u00a0"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/cs500261k"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b01115"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b02579"},{"key":"e_1_2_8_34_1","unstructured":"\u00a0"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00681H"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.202100666"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201700678"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202003650"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b02735"},{"key":"e_1_2_8_40_1","unstructured":"\u00a0"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b00620"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1QO01842F"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2QO01706G"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2GC00224H"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201801492"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC02465D"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150915111741"},{"key":"e_1_2_8_48_1","unstructured":"For selected modern methods to prepare sulfonamides see:"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0397658"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja405949a"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol403072r"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201400037"},{"key":"e_1_2_8_52_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201400037"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b03545"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201508370"},{"key":"e_1_2_8_54_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201508370"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b04532"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2GC03218J"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b03299"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c00183"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.9b00552"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c03505"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.2c00777"},{"key":"e_1_2_8_62_1","unstructured":"For selected functionalization of sulfonamidesviasulfonyl radical Intermediates. see:"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC02266K"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c05669"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c04144"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c01260"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c01442"},{"key":"e_1_2_8_68_1","unstructured":"For selected functionalization of sulfonamidesviasulfonyl radical Intermediates see:"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201910895"},{"key":"e_1_2_8_69_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201910895"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202000022"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b11800"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9QO01402K"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b10985"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202000022"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202102748"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202000484"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2022.132830"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat2117"},{"key":"e_1_2_8_79_1","unstructured":"\u00a0"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00054A"},{"key":"e_1_2_8_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201803102"},{"key":"e_1_2_8_81_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201803102"},{"key":"e_1_2_8_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2020.07.010"},{"key":"e_1_2_8_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-021-00266-5"},{"key":"e_1_2_8_84_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00444"},{"key":"e_1_2_8_85_1","unstructured":"For selected recently works invovled EnT-mediated difunctionalization of alkenes by homolytic cleavage of N\u2212O bond. see:"},{"key":"e_1_2_8_86_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201904671"},{"key":"e_1_2_8_86_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201904671"},{"key":"e_1_2_8_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201912907"},{"key":"e_1_2_8_87_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201912907"},{"key":"e_1_2_8_88_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09244"},{"key":"e_1_2_8_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-022-00883-3"},{"key":"e_1_2_8_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-020-00553-2"},{"key":"e_1_2_8_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-022-01008-w"},{"key":"e_1_2_8_92_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC06497A"},{"key":"e_1_2_8_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202212292"},{"key":"e_1_2_8_93_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202212292"},{"key":"e_1_2_8_94_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202107118"},{"key":"e_1_2_8_94_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202107118"},{"key":"e_1_2_8_95_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2QO00268J"},{"key":"e_1_2_8_96_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c07170"},{"key":"e_1_2_8_97_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2QO00741J"},{"key":"e_1_2_8_98_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01064"},{"key":"e_1_2_8_99_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c03233"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c11295"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1081\/SCC-100103318"},{"key":"e_1_2_8_102_1","unstructured":"Deposition numbers CCDC 2242719 (for68) contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service."},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp047583"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202301392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:01:28Z","timestamp":1760274088000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202301392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,28]]},"references-count":113,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/chem.202301392"],"URL":"https:\/\/doi.org\/10.1002\/chem.202301392","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,28]]},"assertion":[{"value":"2023-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202301392"}}