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These compounds are cytotoxic and selective against a small panel of renal, bladder, ovarian, and breast cancer cell lines. We selected a trinuclear PtAu<jats:sub>2<\/jats:sub> compound containing the Pt<jats:sup>IV<\/jats:sup> core based on oxaliplatin, to further investigate its cell\u2010death pathway, cell and organelle uptake and anticancer effects against the triple\u2010negative breast cancer (TNBC) MDA\u2010MB\u2010231\u2005cell line. This compound induces apoptosis and accumulates mainly in the nucleus and mitochondria. It also exerts remarkable antimigratory and antiangiogenic properties, and has a potent cytotoxic effect against TNBC 3D spheroids. 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