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As a step towards this ambitious goal, here we describe the synthesis of a novel poly(ethylene glycol)\u2010based crosslinker, reactive towards nucleophiles, that effectively degrades with UV light (405\u2005nm). We demonstrate its utility for the fabrication of the first protocell membranes capable of light\u2010induced disassembly, for the photo\u2010generation of patterns of protocells, and for the modulation of protocell membrane permeability. Overall, our results not only open up new avenues towards the engineering of spatially organised, communicating networks of protocells, and of micro\u2010compartmentalised systems for information storage and release, but also have important implications for other research fields such as drug delivery and soft materials chemistry.<\/jats:p>","DOI":"10.1002\/chem.202302058","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T07:19:41Z","timestamp":1690442381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Photo\u2010degradable Crosslinker for the Development of Light\u2010responsive Protocell Membranes"],"prefix":"10.1002","volume":"29","author":[{"given":"Patrick J.","family":"Grimes","sequence":"first","affiliation":[{"name":"School of Chemistry University of Bristol  Cantock's Close Bristol BS8 1TS UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Jenkinson\u2010Finch","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Bristol  Cantock's Close Bristol BS8 1TS UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-5435","authenticated-orcid":false,"given":"Henry E.","family":"Symons","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Bristol  Cantock's Close Bristol BS8 1TS UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8025-960X","authenticated-orcid":false,"given":"Wuge H.","family":"Briscoe","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Bristol  Cantock's Close Bristol BS8 1TS UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9933-2309","authenticated-orcid":false,"given":"Sebastien","family":"Rochat","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Bristol  Cantock's Close Bristol BS8 1TS UK"},{"name":"School of Engineering Mathematics and Technology University of Bristol Ada Lovelace Building  Tankard's Close Bristol BS8 1TW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3012-8964","authenticated-orcid":false,"given":"Stephen","family":"Mann","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Bristol  Cantock's Close Bristol BS8 1TS UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2575-5816","authenticated-orcid":false,"given":"Pierangelo","family":"Gobbo","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences University of Trieste  Via L. 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