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However, progress has been hindered by the low synthetic efficiency of many nanocluster syntheses. In this study, we present the first high\u2010throughput syntheses of homo\u2010gold, homo\u2010copper, and gold\u2010copper alloy nanoclusters in dichloromethane at room temperature. Through high\u2010throughput screening, we successfully obtained three nanoclusters in a single reaction: Au\n                    <jats:sub>18<\/jats:sub>\n                    (SC\n                    <jats:sub>6<\/jats:sub>\n                    H\n                    <jats:sub>11<\/jats:sub>\n                    )\n                    <jats:sub>14<\/jats:sub>\n                    , [Au\n                    <jats:sub>41<\/jats:sub>\n                    Cu\n                    <jats:sub>66<\/jats:sub>\n                    (SC\n                    <jats:sub>6<\/jats:sub>\n                    H\n                    <jats:sub>11<\/jats:sub>\n                    )\n                    <jats:sub>44<\/jats:sub>\n                    ](SbF\n                    <jats:sub>6<\/jats:sub>\n                    )\n                    <jats:sub>3<\/jats:sub>\n                    , and an unidentified copper cluster (referred to as\n                    <jats:bold>\n                      Au\n                      <jats:sub>18<\/jats:sub>\n                    <\/jats:bold>\n                    ,\n                    <jats:bold>\n                      Au\n                      <jats:sub>41<\/jats:sub>\n                      Cu\n                      <jats:sub>66<\/jats:sub>\n                    <\/jats:bold>\n                    <jats:sub>,<\/jats:sub>\n                    and\n                    <jats:bold>Cu\u2212NC<\/jats:bold>\n                    ). The optimized synthesis route was achieved with the assistance of machine learning for experimental data analysis, which also guided the synthesis of other metal nanoclusters such as Au\n                    <jats:sub>40<\/jats:sub>\n                    Cu\n                    <jats:sub>34<\/jats:sub>\n                    (4\u2010S\u2010PhF)\n                    <jats:sub>40<\/jats:sub>\n                    (\n                    <jats:bold>\n                      Au\n                      <jats:sub>40<\/jats:sub>\n                      Cu\n                      <jats:sub>34<\/jats:sub>\n                    <\/jats:bold>\n                    ), [Au\n                    <jats:sub>6<\/jats:sub>\n                    Cu\n                    <jats:sub>6<\/jats:sub>\n                    (SPh)\n                    <jats:sub>12<\/jats:sub>\n                    ]\n                    <jats:sub>n<\/jats:sub>\n                    ([\n                    <jats:bold>\n                      Au\n                      <jats:sub>6<\/jats:sub>\n                      Cu\n                      <jats:sub>6<\/jats:sub>\n                    <\/jats:bold>\n                    ]\n                    <jats:sub>n<\/jats:sub>\n                    ), and Au\n                    <jats:sub>18<\/jats:sub>\n                    Cu\n                    <jats:sub>32<\/jats:sub>\n                    (3,5\u2010C\n                    <jats:sub>8<\/jats:sub>\n                    H\n                    <jats:sub>9<\/jats:sub>\n                    S)\n                    <jats:sub>36<\/jats:sub>\n                    (\n                    <jats:bold>\n                      Au\n                      <jats:sub>18<\/jats:sub>\n                      Cu\n                      <jats:sub>32<\/jats:sub>\n                    <\/jats:bold>\n                    )). This research demonstrates that high\u2010throughput screening can be a valuable tool in accelerating the development of nanocluster syntheses.\n                  <\/jats:p>","DOI":"10.1002\/chem.202302602","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T07:08:35Z","timestamp":1716448115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Discovering of Atomically Precise Metal Nanoclusters by High\u2010Throughput Syntheses Platform"],"prefix":"10.1002","volume":"30","author":[{"given":"Li","family":"Tang","sequence":"first","affiliation":[{"name":"Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering College of Materials Science and Engineering Qingdao University of Science and Technology  Qingdao 266042 P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education Xiangtan University  Xiangtan Hunan 411105 P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering College of Materials Science and Engineering Qingdao University of Science and Technology  Qingdao 266042 P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Chemistry Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education Xiangtan University  Xiangtan Hunan 411105 P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0403-3953","authenticated-orcid":false,"given":"Shuxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering College of Materials Science and Engineering Qingdao University of Science and Technology  Qingdao 266042 P.\u2005R. 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