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The reaction was performed under organocatalysis by using a quinine\u2010derived primary amine as the catalyst in combination with a Br\u00f8nsted acid as the co\u2010catalyst. High yields (up to 89\u2009%) and excellent enantioselectivities (up to 97\u2009%\u2005<jats:italic>ee<\/jats:italic>) were observed. For methyl alkyl ketones containing a larger alkyl substituent, specific regioselective addition to the C=N bond is favored at the methyl group. On the contrary, ketones containing a smaller alkyl substituent or hydroxyacetone substrates gave major syn selective Mannich products at the methylene group.<\/jats:p>","DOI":"10.1002\/chem.202302904","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T01:28:40Z","timestamp":1699406920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Enantioselective Synthesis of Biphenyl\u2010Bridged \u03f5\u2010Sultams by Organocatalytic Mannich Reactions of Cyclic N\u2010Sulfonylimines with Unactivated Ketones"],"prefix":"10.1002","volume":"30","author":[{"given":"Ying","family":"Du","sequence":"first","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province Henan University  Kaifeng Henan 475004 P. R. 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