{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:59:19Z","timestamp":1775487559137,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"70","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QB026"],"award-info":[{"award-number":["ZR2020QB026"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2023,12,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Environmental issues are becoming more and more prominent, and bio\u2010based polymers are essential to alleviate environmental degradation by replacing traditional polymers. With this context, a new family of functional isosorbide\u2010based polyesters and polyamides with high glass transition temperature are prepared via Passerini\u2010Three component polymerization (P\u20103CP). To optimize the P\u20103CP conditions, the influence of the polymerization solvent, temperature, feed ratio on the molar mass of final polymers are investigated. The higher molar mass (up to 10100\u2005g\/mol) and yield (&gt;70\u2009%) are achieved under very mild conditions (30\u2009\u00b0C, standard atmosphere). Functional side groups, such as alkenyl, alkynyl and methyl ester, were introduced into polymer structure via P\u20103CP by using functional isocyanides. The obtained polyesters and polyamides are characterized by nuclear magnetic resonance (NMR) and infrared (IR) spectroscopies, differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). All polymers are thermal stable and amorphous with variable glass transition temperatures (T<jats:sub>g<\/jats:sub>). The obtained polyester has T<jats:sub>g<\/jats:sub> up to 87.5\u2009\u00b0C, while the T<jats:sub>g<\/jats:sub> of polyamides (ISPA\u20102) is detected to be 97.5\u2009\u00b0C depending on the amide bonds in the polymer backbone and the benzene ring side groups. The cytotoxicity is investigated by the CCK\u20108 assay against mBMSC cells to confirm the biological safety. Overall, this novel strategy provides an efficient approach to produce functional isosorbide\u2010based polyesters and polyamides, which are promising prospect for being applied to biodegradable materials.<\/jats:p>","DOI":"10.1002\/chem.202303005","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T10:23:47Z","timestamp":1697106227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis of Functional Isosorbide\u2010Based Polyesters and Polyamides by Passerini Three\u2010Component Polymerization"],"prefix":"10.1002","volume":"29","author":[{"given":"Xiaofei","family":"Sun","sequence":"first","affiliation":[{"name":"Key Laboratory of Rubber-plastics Ministry of Education School of Polymer Science and Engineering Qingdao University of Science and Technology  Zhengzhou Rd. 53 CN-266042 Qingdao 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