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However, methods for their introduction into aliphatic carbon chains remain very limited. A potentially general route to integrate the fluorinated scaffolds into organic molecules involves insertion of fluorine\u2010containing carbenes into C(sp<jats:sup>3<\/jats:sup>)\u2212H bonds. The electron\u2010withdrawing characteristics of perfluoroalkyl groups enhances the reactivity of these carbenes which should enable the functionalization of unactivated C(sp<jats:sup>3<\/jats:sup>)\u2212H bonds. Curiously, it appears that use of perfluoroalkyl\u2010containing carbenes in alkane C\u2212H functionalization is exceedingly rare. 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