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Following either conjugate addition with an amine or nitromethane, or osmium(VIII)\u2010catalysed dihydoxylation, rearrangement through a four\u2010atom ring expansion takes place spontaneously to form the ring expanded products. A second ring expansion can also be performed following a second iteration of imide formation and alkene functionalisation\/ring expansion. In the dihydroxylation series, three\u2010 or four\u2010atom ring expansion can be performed selectively, depending on whether the reaction is under kinetic or thermodynamic control.<\/jats:p>","DOI":"10.1002\/chem.202303270","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T18:22:14Z","timestamp":1700590934000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Divergent Cascade Ring\u2010Expansion Reactions of Acryloyl Imides"],"prefix":"10.1002","volume":"30","author":[{"given":"Will E.","family":"Orukotan","sequence":"first","affiliation":[{"name":"Department of Chemistry University of York  York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleopas Y.","family":"Palate","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of York  York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Pogr\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of York  York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Bobinski","sequence":"additional","affiliation":[{"name":"Organisch-Chemisches Institut Universit\u00e4t Heidelberg  Im Neuenheimer Feld 270 69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan G.","family":"Epton","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of York  York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Duff","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of York  York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian C.","family":"Whitwood","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of York  York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Grogan","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of York  York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Lynam","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of York  York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-5156","authenticated-orcid":false,"given":"William P.","family":"Unsworth","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of York  York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo8001276"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015024108"},{"key":"e_1_2_8_4_1","unstructured":"\u00a0"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200300626"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200804486"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00084"},{"key":"e_1_2_8_8_1","unstructured":"\u00a0"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201201787"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201601836"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201605337"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b03221"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6b03399"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC05311E"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202300140"},{"key":"e_1_2_8_16_1","unstructured":"For key reviews on cascade reactions see:"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar050113t"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/b903290h"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1590877"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.7b03440"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00947C"},{"key":"e_1_2_8_22_1","unstructured":"For key reviews of ring expansion chemistry see:"},{"key":"e_1_2_8_23_2","unstructured":"M. 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