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State\u2010of\u2010the\u2010art synthesis of formamides relies on the use of an excess amount of reagents, giving copious waste and thus poor atom\u2010economy. Here, we report the first example of direct synthesis of N\u2010formamides by coupling two challenging reactions, namely reductive amination of carbonyl compounds, particularly biomass\u2010derived aldehydes and ketones, and fixation of CO<jats:sub>2<\/jats:sub> in the presence of H<jats:sub>2<\/jats:sub> over a metal\u2010organic framework supported ruthenium catalyst, Ru\/MFM\u2010300(Cr). Highly selective production of N\u2010formamides has been observed for a wide range of carbonyl compounds. Synchrotron X\u2010ray powder diffraction reveals the presence of strong host\u2010guest binding interactions via hydrogen bonding and parallel\u2010displaced \u03c0\u22c5\u22c5\u22c5\u03c0 interactions between the catalyst and adsorbed substrates facilitating the activation of substrates and promoting selectivity to formamides. The use of multifunctional porous catalysts to integrate CO<jats:sub>2<\/jats:sub> utilisation in the synthesis of formamide products will have a significant impact in the sustainable synthesis of feedstock chemicals.<\/jats:p>","DOI":"10.1002\/chem.202303289","type":"journal-article","created":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T23:14:24Z","timestamp":1698621264000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Direct Synthesis of N\u2010formamides by Integrating Reductive Amination of Ketones and Aldehydes with CO<sub>2<\/sub> Fixation in a Metal\u2010Organic Framework"],"prefix":"10.1002","volume":"30","author":[{"given":"Wenyuan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Manchester  Manchester M13 9PL 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