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This review provides an update of the most relevant research efforts towards the development of novel cancer theranostic agents using Re and Tc\u2010based compounds interacting with specific DNA structures. This includes a variety of homometallic complexes, namely those containing M(CO)<jats:sub>3<\/jats:sub> (M=Re, Tc) moieties, that exhibit different modes of interaction with DNA, such as covalent binding, intercalation, groove binding or G\u2010quadruplex DNA binding. Additionally, heterometallic complexes, designed to potentiate synergistic effects of different metal centers to improve DNA\u2010targeting, cytotoxicity and fluorescence properties, are also reviewed. Particular attention is also given to <jats:sup>99m<\/jats:sup>Tc\u2010 and <jats:sup>188<\/jats:sup>Re\u2010labeled oligonucleotides that have been widely explored to develop imaging and therapeutic radiopharmaceuticals through the <jats:italic>in\u2005vivo<\/jats:italic> hybridization with a specific complementary DNA or RNA target sequence to provide useful molecular tools in precision medicine for cancer diagnosis and treatment. Finally, the need for further improvement of DNA\u2010targeted Re and Tc\u2010based compounds as potential therapeutic and diagnostic agents is highlighted, and future directions are discussed.<\/jats:p>","DOI":"10.1002\/chem.202303591","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T12:19:15Z","timestamp":1701433155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["DNA\u2010Targeted Complexes of Tc and Re for Biomedical Applications"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-6633","authenticated-orcid":false,"given":"Elisa","family":"Palma","sequence":"first","affiliation":[{"name":"C<sup>2<\/sup>TN \u2013 Centro de Ci\u00eancias e Tecnologias, Nucleares Instituto Superior T\u00e9cnico Universidade de Lisboa  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana F.","family":"Santos","sequence":"additional","affiliation":[{"name":"C<sup>2<\/sup>TN \u2013 Centro de Ci\u00eancias e Tecnologias, Nucleares Instituto Superior T\u00e9cnico Universidade de Lisboa  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lia","family":"Fernandes","sequence":"additional","affiliation":[{"name":"C<sup>2<\/sup>TN \u2013 Centro de Ci\u00eancias e Tecnologias, Nucleares Instituto Superior T\u00e9cnico Universidade de Lisboa  Portugal"},{"name":"DECN \u2013 Departamento de Engenharia e Ci\u00eancias Nucleares Instituto Superior T\u00e9cnico Universidade de Lisboa  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9164-0913","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Paulo","sequence":"additional","affiliation":[{"name":"C<sup>2<\/sup>TN \u2013 Centro de Ci\u00eancias e Tecnologias, Nucleares Instituto Superior T\u00e9cnico Universidade de Lisboa  Portugal"},{"name":"DECN \u2013 Departamento de Engenharia e Ci\u00eancias Nucleares Instituto Superior T\u00e9cnico Universidade de Lisboa  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"crossref","unstructured":"U. 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