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Their activity on the aggregation of the human islet amyloid polypeptide (hIAPP) amyloid protein was evaluated by fluorescence spectroscopy and mass spectrometry. The fluorine labelling of these foldamers allowed the analysis of their interaction with the target protein. We demonstrated that the preferred extended conformation of homotriazolamers of 1,4\u2010Tz\u2212CF<jats:sub>2<\/jats:sub> unit increases the aggregation of hIAPP, while the hairpin\u2010like conformation of more flexible heterotriazolamers containing two 1,4\u2010Tz\u2212CF<jats:sub>2<\/jats:sub> units mixed with natural amino acids from the hIAPP sequence reduces it, and more efficiently than the parent natural peptide. The longer heterotriazolamers having three 1,4\u2010Tz\u2212CF<jats:sub>2<\/jats:sub> units adopting more folded hairpin\u2010like and ladder\u2010like structures similar to short multi\u2010stranded \u03b2\u2010sheets have no effect. This work demonstrates that a good balance between the structuring and flexibility of these foldamers is necessary to allow efficient interaction with the target protein.<\/jats:p>","DOI":"10.1002\/chem.202303887","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:50:13Z","timestamp":1710341413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Composition and Conformation of Hetero\u2010 <i>versus<\/i> Homo\u2010Fluorinated Triazolamers Influence their Activity on Islet Amyloid Polypeptide Aggregation"],"prefix":"10.1002","volume":"30","author":[{"given":"Jos\u00e9","family":"Laxio Arenas","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CNRS BioCIS, Bat. 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