{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:51:14Z","timestamp":1776088274709,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019003","name":"Enamine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007684","name":"Ministry of Education and Science of Ukraine","doi-asserted-by":"publisher","award":["0121U100387 (21BF037-01M); 0122U001962 (22BF037-02)"],"award-info":[{"award-number":["0121U100387 (21BF037-01M); 0122U001962 (22BF037-02)"]}],"id":[{"id":"10.13039\/501100007684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2024,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A safe and efficient method for the in\u2010situ preparation of (diazomethyl)dimethylphosphine oxide \u2013 a hereto unexplored diazoalkane reagent \u2013 is developed. The method is based on the diazotization of the corresponding P(O)Me\n                    <jats:sub>2<\/jats:sub>\n                    \u2010substituted amine (readily available in multigram quantities) in non\u2010aqueous media. The protocol provides the target product as ca. 1.5\u2005M CHCl\n                    <jats:sub>3<\/jats:sub>\n                    solution which is stable at \u221218\u2009\u00b0C. The utility of the synthesized diazoalkane is illustrated by its [3+2] cycloaddition with electron\u2010poor alkynes and alkenes providing the corresponding P(O)Me\n                    <jats:sub>2<\/jats:sub>\n                    \u2010substituted pyrazoles and pyrazolines with moderate to good efficiency. In this view, the title compound represents and an important extension of medicinally relevant phosphine oxide reagents.\n                  <\/jats:p>","DOI":"10.1002\/chem.202303972","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T09:58:17Z","timestamp":1708595897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["(Diazomethyl)dimethylphosphine Oxide \u2013 A Diazoalkane Reagent for [3+2] Cycloadditions"],"prefix":"10.1002","volume":"30","author":[{"given":"Evgeniy Y.","family":"Slobodyanyuk","sequence":"first","affiliation":[{"name":"Enamine Ltd.  Winston Churchill Street 78 Ky\u0457v 02094 Ukraine"},{"name":"Taras Shevchenko National University of Kyiv  Volodymyrska Street 60 Ky\u0457v 01601 Ukraine"},{"name":"Institute of Organic Chemistry National Academy of Sciences of Ukraine  Akademik Kukhar Street 5 Ky\u0457v 02660 Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Tarasiuk","sequence":"additional","affiliation":[{"name":"Enamine Ltd.  Winston Churchill Street 78 Ky\u0457v 02094 Ukraine"},{"name":"Taras Shevchenko National University of Kyiv  Volodymyrska Street 60 Ky\u0457v 01601 Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taras","family":"Pasichnyk","sequence":"additional","affiliation":[{"name":"Enamine Ltd.  Winston Churchill Street 78 Ky\u0457v 02094 Ukraine"},{"name":"Taras Shevchenko National University of Kyiv  Volodymyrska Street 60 Ky\u0457v 01601 Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitriy M.","family":"Volochnyuk","sequence":"additional","affiliation":[{"name":"Enamine Ltd.  Winston Churchill Street 78 Ky\u0457v 02094 Ukraine"},{"name":"Taras Shevchenko National University of Kyiv  Volodymyrska Street 60 Ky\u0457v 01601 Ukraine"},{"name":"Institute of Organic Chemistry National Academy of Sciences of Ukraine  Akademik Kukhar Street 5 Ky\u0457v 02660 Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmytro O.","family":"Sibgatulin","sequence":"additional","affiliation":[{"name":"Enamine Ltd.  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