{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:17:39Z","timestamp":1793121459470,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1127 ChemBioSys, subprojects A01 and C03"],"award-info":[{"award-number":["SFB 1127 ChemBioSys, subprojects A01 and C03"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1127 ChemBioSys, subproject A01"],"award-info":[{"award-number":["SFB 1127 ChemBioSys, subproject A01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2051 Balance of the Microverse"],"award-info":[{"award-number":["EXC 2051 Balance of the Microverse"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 275\/442-1 FUGG"],"award-info":[{"award-number":["INST 275\/442-1 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007636","name":"Deutsche Bundesstiftung Umwelt","doi-asserted-by":"publisher","award":["Doctoral Fellowship"],"award-info":[{"award-number":["Doctoral Fellowship"]}],"id":[{"id":"10.13039\/100007636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004079","name":"Konrad-Adenauer-Stiftung","doi-asserted-by":"publisher","award":["Doctoral Fellowship"],"award-info":[{"award-number":["Doctoral Fellowship"]}],"id":[{"id":"10.13039\/501100004079","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021828","name":"German Academic Exchange Service","doi-asserted-by":"publisher","award":["Doctoral Fellowship"],"award-info":[{"award-number":["Doctoral Fellowship"]}],"id":[{"id":"10.13039\/100021828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011264","name":"FP7 People: Marie-Curie Actions","doi-asserted-by":"publisher","award":["796194 THALLMORPHAL"],"award-info":[{"award-number":["796194 THALLMORPHAL"]}],"id":[{"id":"10.13039\/100011264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010959","name":"Th\u00fcringer Ministerium f\u00fcr Wirtschaft, Wissenschaft und Digitale Gesellschaft","doi-asserted-by":"publisher","award":["2015 FGI 0021"],"award-info":[{"award-number":["2015 FGI 0021"]}],"id":[{"id":"10.13039\/501100010959","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2024,3,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A fully enantioselective, catalytic synthesis of the algal morphogen (\u2212)\u2010thallusin using polyene cyclization chemistry is reported. The synthesis features dedicated precursor design, introduction of a TMS\u2010substituted arene as a regioselective terminator, very high enantiomer excess (<jats:italic>ee<\/jats:italic>) on gram scale, and productive scaffold functionalization. Furthermore, an <jats:italic>ee<\/jats:italic> determination methodology of thallusin samples was developed, and the <jats:italic>ee<\/jats:italic> of biosynthesized thallusin was determined. Fe(III)\u2010uptake studies demonstrated that the cellular uptake of iron facilitated by thallusin derivatives was independent of their morphogenic activity, suggesting their active import via siderophore transporters as a shuttle system.<\/jats:p>","DOI":"10.1002\/chem.202304007","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T13:04:15Z","timestamp":1706187855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Enantioselective Total Synthesis of the Morphogen (\u2212)\u2010Thallusin and Mediated Uptake of Fe(III) into the Green Seaweed <i>Ulva<\/i>"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3085-0642","authenticated-orcid":false,"given":"Paul","family":"Wienecke","sequence":"first","affiliation":[{"name":"Friedrich Schiller University Jena Institute of Organic Chemistry and Macromolecular Chemistry  Humboldtstr. 10 D-07743 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3869-8187","authenticated-orcid":false,"given":"Johann F.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Friedrich Schiller University Jena Institute of Inorganic and Analytical Chemistry  Lessingstr. 8 D-07743 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0923-4500","authenticated-orcid":false,"given":"Cristina F.","family":"Morales\u2010Reyes","sequence":"additional","affiliation":[{"name":"Friedrich Schiller University Jena Institute of Inorganic and Analytical Chemistry  Lessingstr. 8 D-07743 Jena Germany"},{"name":"New address: Universidad de Santiago de Chile (USACH)  Facultad de Qu\u00edmica y Biolog\u00eda  Santiago 9170022 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-9925","authenticated-orcid":false,"given":"Seema","family":"Dhiman","sequence":"additional","affiliation":[{"name":"Friedrich Schiller University Jena Institute of Organic Chemistry and Macromolecular Chemistry  Humboldtstr. 10 D-07743 Jena Germany"},{"name":"New address: SRM University Department of Chemistry  Andhra Pradesh 522502 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-4160","authenticated-orcid":false,"given":"Thomas","family":"Wichard","sequence":"additional","affiliation":[{"name":"Friedrich Schiller University Jena Institute of Inorganic and Analytical Chemistry  Lessingstr. 8 D-07743 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0792-1422","authenticated-orcid":false,"given":"Hans\u2010Dieter","family":"Arndt","sequence":"additional","affiliation":[{"name":"Friedrich Schiller University Jena Institute of Organic Chemistry and Macromolecular Chemistry  Humboldtstr. 10 D-07743 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.5670\/oceanog.2016.91"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2008.05.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13021-015-0040-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.14728"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3354\/aei00319"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12860"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/eraa066"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1508\/cytologia.87.17"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105486"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2022.04.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/bot-2016-0083"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2015.00086"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol0605777"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol062970i"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2007.04.075"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo501720b"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202206746"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2022.128845"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0045-2068(76)90016-X"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB00375C"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19540370404"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19570400719"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr040623l"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja310386m"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00279a028"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/p19950000097"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo971098b"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/P19920001953"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol015810"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol026494h"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)88362-9"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1975.1195"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00174a024"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b01733"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00282a030"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)70127-4"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol302593z"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol500039s"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo801028y"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1986-31697"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c00176"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200454084"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0202255"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200300152"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0690(200206)2002:12<1877::AID-EJOC1877>3.0.CO;2-U"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol801691c"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)96730-3"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00362a053"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/md20110690"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.08.015"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2016.00131"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.2.121"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202304007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:22:35Z","timestamp":1760286155000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202304007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":52,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2024,3,25]]}},"alternative-id":["10.1002\/chem.202304007"],"URL":"https:\/\/doi.org\/10.1002\/chem.202304007","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]},"assertion":[{"value":"2023-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202304007"}}