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Within this report, we present the use of triethyloxonium tetrafluoroborate in Sar\u2010NCA synthesis with focus on amino acid and chloride impurities to avoid the sublimation of Sar\u2010NCAs. With a view towards upscaling into kilogram or ton scale, a new methodology of monomer purification is introduced by utilizing the Meerwein's Salt triethyloxonium tetrafluoroborate to remove chloride impurities by covalent binding and converting chloride ions into volatile products within a single step. The novel straightforward technique enables access to monomers with significantly reduced chloride content (&lt;100\u2005ppm) compared to Sar\u2010NCA derived by synthesis or sublimation. The derived monomers enable the controlled\u2010living polymerization in DMF and provide access to pSar polymers with Poisson\u2010like molecular weight distribution within a high range of chain lengths (X<jats:sub>n<\/jats:sub> 25\u2013200). In conclusion, the reported method can be easily applied to Sar\u2010NCA synthesis or purification of commercially available pSar\u2010NCAs and eases access to well\u2010defined hetero\u2010telechelic pSar polymers.<\/jats:p>","DOI":"10.1002\/chem.202304375","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T11:54:13Z","timestamp":1712058853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Utility of Triethyloxonium Tetrafluoroborate for Chloride Removal during Sarcosine <i>N<\/i>\u2010Carboxyanhydride Synthesis: Improving NCA Purity"],"prefix":"10.1002","volume":"30","author":[{"given":"Leon","family":"Capel\u00f4a","sequence":"first","affiliation":[{"name":"Division of BioTherapeutics Leiden Academic Center for Drug Research (LACDR) University Leiden  Einsteinweg 55 Leiden 2333 CC The Netherlands"},{"name":"Department of Dermatology University Medical Center Johannes Gutenberg-University Mainz (JGU)  Obere Zahlbacher Stra\u00dfe 63 55131 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Miravet Mart\u00ed","sequence":"additional","affiliation":[{"name":"Curapath  Av. 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