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The G\u2010quadruplex is formed by a 34\u2010nt DNA sequence, <jats:italic>d<\/jats:italic>[CAG<jats:sub>3<\/jats:sub>T<jats:sub>2<\/jats:sub>A<jats:sub>2<\/jats:sub>G<jats:sub>3<\/jats:sub>TATA<jats:sub>2<\/jats:sub>CT<jats:sub>3<\/jats:sub>AG<jats:sub>4<\/jats:sub>T<jats:sub>2<\/jats:sub>AG<jats:sub>3<\/jats:sub>T<jats:sub>2<\/jats:sub>], named UpsB\u2010Q\u20101. This sequence is found within promoters of the <jats:italic>var<\/jats:italic> genes of <jats:italic>Plasmodium falciparum<\/jats:italic>, which play a key role in malaria pathogenesis and evasion of the immune system. The [3+1]\u2010hybrid G\u2010quadruplex formed under physiologically relevant conditions exhibits a unique equilibrium between two structures, both stabilized by base stacking and non\u2010canonical hydrogen bonding. Unique equilibrium of the two closely related 3D structures originates from a North\u2010South repuckering of deoxyribose moiety of residue T27 in the lateral loop. Besides the 12 guanines involved in three G\u2010quartets, most residues in loop regions are involved in interactions at both G\u2010quartet\u2010loop interfaces.<\/jats:p>","DOI":"10.1002\/chem.202401190","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T07:24:50Z","timestamp":1713770690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Solution\u2010State Structure of a Long\u2010Loop G\u2010Quadruplex Formed Within Promoters of <i>Plasmodium falciparum<\/i> B <i>var<\/i> Genes"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0752-7855","authenticated-orcid":false,"given":"Marina","family":"Juriba\u0161i\u0107 Kulcs\u00e1r","sequence":"first","affiliation":[{"name":"Slovenian NMR Center National Institute of Chemistry  Hajdrihova 19 SI-1000 Ljubljana Slovenia"},{"name":"Division of Physical Chemistry Ru\u0111er Bo\u0161kovi\u0107 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