{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:06:01Z","timestamp":1788476761961,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"47","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2021-03950"],"award-info":[{"award-number":["RGPIN-2021-03950"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["CRC-2020-00101"],"award-info":[{"award-number":["CRC-2020-00101"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2024,8,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydrogels are of interest for a wide range of applications. The ability to control when the hydrogel degrades can provide beneficial properties such as controlled degradation in the environment or the stimulated release of drugs or cells. Self\u2010immolative polymers are a class of degradable polymers that undergo complete end\u2010to\u2010end depolymerization upon the application of a stimulus. They have been explored for hydrogel development, but the ability to prepare and selectively degrade self\u2010immolative hydrogels under neutral aqueous conditions has so far been limited. We describe here the preparation of water\u2010soluble polyglyoxylamides with cross\u2010linkable pendent azides and their cross\u2010linking to form hydrogels with 4\u2010arm poly(ethylene glycol)s having unstrained and strained alkynes using copper\u2010assisted and strain\u2010promoted azide\u2010alkyne click chemistry respectively. The influence of pendent azide density and solution polymer content on the resulting hydrogels was evaluated. A polyglyoxylamide with a 70\u2009:\u200930 ratio of pendent hydroxyl:azide successfully provided hydrogels with compressive moduli ranging from 1.3\u20136.3\u2005kPa under copper\u2010free conditions at 10\u201320\u2009% (w\/w) of polymer in phosphate\u2010buffered saline. Selective depolymerization and degradation of the hydrogels upon irradiation with light was demonstrated, resulting in reductions in the compressive moduli and the release of depolymerization products that were detected by NMR spectroscopy.<\/jats:p>","DOI":"10.1002\/chem.202401324","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T23:39:30Z","timestamp":1718926770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Self\u2010immolative Polymer Hydrogels via <i>In Situ<\/i> Gelation"],"prefix":"10.1002","volume":"30","author":[{"given":"Jared D.","family":"Pardy","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering The University of Western Ontario  1151 Richmond Street N6A 5B9 London, Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-1185","authenticated-orcid":false,"given":"Burak","family":"Tavsanli","sequence":"additional","affiliation":[{"name":"Department of Chemistry The University of Western Ontario  1151 Richmond St. N6A 5B7 London, Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1805-3373","authenticated-orcid":false,"given":"Quinton E. 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