{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:04:10Z","timestamp":1788498250141,"version":"build-2803163510"},"reference-count":74,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016386","name":"Conselleria de Innovaci\u00f3n, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana","doi-asserted-by":"publisher","award":["APOSTD\/2020\/065"],"award-info":[{"award-number":["APOSTD\/2020\/065"]}],"id":[{"id":"10.13039\/501100016386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016386","name":"Conselleria de Innovaci\u00f3n, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana","doi-asserted-by":"publisher","award":["CIPROM\/2021\/030"],"award-info":[{"award-number":["CIPROM\/2021\/030"]}],"id":[{"id":"10.13039\/501100016386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CA18202"],"award-info":[{"award-number":["CA18202"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019-110751RD-I00"],"award-info":[{"award-number":["PID2019-110751RD-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite decades of research, Parkinson's disease is still an idiopathic pathology for which no cure has yet been found. This is partly explained by the multifactorial character of most neurodegenerative syndromes, whose generation involves multiple pathogenic factors. In Parkinson's disease, two of the most important ones are the aggregation of \u03b1\u2010synuclein and oxidative stress. In this work, we address both issues by synthesizing a multifunctional nanozyme based on grafting a pyridinophane ligand that can strongly coordinate Cu<jats:sup>II<\/jats:sup>, onto biodegradable PEGylated polyester nanoparticles. The resulting nanozyme exhibits remarkable superoxide dismutase activity together with the ability to inhibit the self\u2010induced aggregation of \u03b1\u2010synuclein into amyloid\u2010type fibrils. Furthermore, the combination of the chelator and the polymer produces a cooperative effect whereby the resulting nanozyme can also halve Cu<jats:sup>II<\/jats:sup>\u2010induced \u03b1\u2010synuclein aggregation.<\/jats:p>","DOI":"10.1002\/chem.202401331","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T08:53:29Z","timestamp":1714467209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Polymeric Nanozyme with SOD Activity Capable of Inhibiting Self\u2010 and Metal\u2010Induced \u03b1\u2010Synuclein Aggregation"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-6961","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Mart\u00ednez\u2010Camarena","sequence":"first","affiliation":[{"name":"ICMol Departament de Qu\u00edmica Inorg\u00e0nica Universitat de Val\u00e8ncia  C\/Catedr\u00e1tico Jos\u00e9 Beltr\u00e1n 2 Paterna 46980 Spain"},{"name":"Institut Galien Paris-Saclay CNRS Universit\u00e9 Paris-Saclay  Orsay 91400 France"},{"name":"Dipartimento di Scienze Chimiche Universit\u00e0 degli Studi di Catania  Viale A. Doria 6 Catania 95125 Italy"},{"name":"MatMoPol Research Group Departamento de Qu\u00edmica Inorg\u00e1nica Facultad de Ciencias Qu\u00edmicas Universidad Complutense de Madrid  Avda. Complutense s\/n Madrid 28040 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9273-5949","authenticated-orcid":false,"given":"Francesco","family":"Bellia","sequence":"additional","affiliation":[{"name":"Istituto di Cristallografia, CNR  P. Gaifami 18 Catania 95126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9154-8842","authenticated-orcid":false,"given":"M.","family":"Paz Clares","sequence":"additional","affiliation":[{"name":"ICMol Departament de Qu\u00edmica Inorg\u00e0nica Universitat de Val\u00e8ncia  C\/Catedr\u00e1tico Jos\u00e9 Beltr\u00e1n 2 Paterna 46980 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8305-081X","authenticated-orcid":false,"given":"Graziella","family":"Vecchio","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche Universit\u00e0 degli Studi di Catania  Viale A. Doria 6 Catania 95125 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1597-0873","authenticated-orcid":false,"given":"Julien","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Institut Galien Paris-Saclay CNRS Universit\u00e9 Paris-Saclay  Orsay 91400 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4601-6505","authenticated-orcid":false,"given":"Enrique","family":"Garc\u00eda\u2010Espa\u00f1a","sequence":"additional","affiliation":[{"name":"ICMol Departament de Qu\u00edmica Inorg\u00e0nica Universitat de Val\u00e8ncia  C\/Catedr\u00e1tico Jos\u00e9 Beltr\u00e1n 2 Paterna 46980 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"World Health Organization Parkinson Disease: A Public Health Approach. Technical Brief ISBN 978-92-4-005098-3 Editor: World Health Organization \u00a9 World Health Organization 2022 pp. 32."},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00218-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3299"},{"key":"e_1_2_8_4_1","unstructured":"GBD 2016 Neurology Collaborators Valery\u2005L. Feigin et\u2005al. Lancet Neurol.2019 18 459"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13031"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-322338"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10367"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202000451"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-130230"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.07.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-017-0340-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202007924"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.08.049"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20163896"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA09350H"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC01926G"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr980432g"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.8b01492"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9DT01800J"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2021.102109"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2018.12.027"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202300035"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.2c04327"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC01257J"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.0c03276"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC02465E"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0137-1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797212"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2008-15314"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC01599F"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc36808k"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA08992F"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c01018"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201201114"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804198115"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.08.005"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0310-y"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1616191114"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25102444"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00001"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00703"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00140"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35265F"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn300489k"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43834-y"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic700643n"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/b924028d"},{"key":"e_1_2_8_49_1","unstructured":"E. Garc\u00eda-Espa\u00f1a M.\u2005P. Clares C. Soriano S. Blasco B. Verdejo J. Gonz\u00e1lez 2012 ES2355784B1."},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja994050j"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2011.02.001"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2018.04.004"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201904885"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2010.04.001"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72989-2"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201904885"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32247"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22396"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-016-3518-7"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.197805221"},{"key":"e_1_2_8_61_1","volume-title":"Bioconjugate Techniques","author":"Hermanson G.","year":"2013"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1GC02251B"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja906709t"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0001-8686(96)00297-7"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05064-3"},{"key":"e_1_2_8_66_1","unstructured":"L.\u2005W. Oberley D.\u2005R. Spitz Handbook of Methods of Oxygen Radicals Research(Ed: R.\u2005A. Grenwald) CRC Press Boca Raton USA1986."},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(71)90370-8"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.09.022"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00451a028"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00498a038"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200400835"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2005.06.006"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10118-020-2439-1"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAB.22.001479"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202401331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:17:40Z","timestamp":1760300260000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202401331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":74,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2024,7,2]]}},"alternative-id":["10.1002\/chem.202401331"],"URL":"https:\/\/doi.org\/10.1002\/chem.202401331","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,22]]},"assertion":[{"value":"2024-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202401331"}}