{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:56:21Z","timestamp":1760316981966,"version":"build-2065373602"},"reference-count":52,"publisher":"Wiley","issue":"45","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2024,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cyclic dipeptides (CDPs) are crucial building blocks for a range of functional nanomaterials due to their simple chemical structure and high molecular stability. In this investigation, we synthesized a set of S\u2010benzyl\u2010L\u2010cysteine\u2010based CDPs (designated as <jats:bold>P1<\/jats:bold>\u2010<jats:bold>P6<\/jats:bold>) and thoroughly examined their self\u2010assembly behavior in a methanol\u2010water solvent to elucidate the relationship between their structure and gelation properties. The hydrophobicity of the amino acids within the CDPs was gradually increased. The present study employed a comprehensive array of analytical techniques, including NMR, FT\u2010IR, AFM, thioflavin\u2010T, congo\u2010red CD, X\u2010ray crystallography, and biophysical calculations like Hirshfield Surface analysis and DFT analysis. These methods revealed that in addition to hydrogen bonding, the hydrophobic nature of the amino acid side chain significantly influences the propensity of CDPs to form hydrogels. Each CDP yielded distinct nanofibrillar networks rich in \u03b2\u2010sheet structures, showcasing unique morphological features. Moreover, we explored the practical application of these CDP\u2010based hydrogels in water purification by utilizing them to remove harmful organic dyes from contaminated water. This application underscores the potential of CDPs in addressing environmental challenges, offering a promising avenue for the future development of these materials in water treatment technologies.<\/jats:p>","DOI":"10.1002\/chem.202401874","type":"journal-article","created":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T22:30:43Z","timestamp":1717972243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Crystal to Hydrogel Transformation in S\u2010Benzyl\u2010L\u2010Cysteine\u2010Containing Cyclic Dipeptides \u2010 Nanostructure Elucidation and Applications"],"prefix":"10.1002","volume":"30","author":[{"given":"Saswati","family":"Ghosh","sequence":"first","affiliation":[{"name":"Organic &amp; Medicinal Chemistry Division Indian Institute of Chemical Biology (CSIR-IICB)  4-Raja S. C. Mullick Road Kolkata 700032 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayim","family":"Sepay","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lady Brabourne College  Suhrawardy Ave Beniapukur, Kolkata, West Bengal 700017 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9898-253X","authenticated-orcid":false,"given":"Biswadip","family":"Banerji","sequence":"additional","affiliation":[{"name":"Organic &amp; Medicinal Chemistry Division Indian Institute of Chemical Biology (CSIR-IICB)  4-Raja S. C. Mullick Road Kolkata 700032 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1238"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199611541"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00164H"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/b609047h"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1062798709000805"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00369"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900181u"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199523111"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3sm51498f"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp802424h"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.200800455"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja100613w"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00176A"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2020.101250"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3SM52244J"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0CC03293J"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar0500923"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9SM02127B"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.06.013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.5b00487"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00439"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010316)40:6<988::AID-ANIE9880>3.0.CO;2-N"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026616999160212120302"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100843a018"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01274a023"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/c39940001401"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/b816664a"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.2011.1143"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.6b01059"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2008.04.156"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.3403"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.7b04373"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/2193-8865-3-12"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA23911K"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT02356F"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11433-014-5427-z"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA04393F"},{"key":"e_1_2_8_38_1","first-page":"1","volume":"61","author":"Ghosh G.","year":"2022","journal-title":"Angew. Chem. - Int. Ed."},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b00417"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560040420"},{"key":"e_1_2_8_41_1","first-page":"783","volume":"56","author":"Adochitei A.","year":"2011","journal-title":"Rev. Roum. Chim."},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2052252515009884"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2005.05.001"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.6b02178"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2005.01.029"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.2166\/wqrj.2007.008"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0956-053X(00)00028-3"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2005.09.010"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm062672f"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200800731"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ra43068e"},{"key":"e_1_2_8_52_1","unstructured":"Deposition numbers (CCDC) 2233567 (for P1) 2233450 (for P2) and 2233563 (for P6) contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe \u201chttp:\/\/www.ccdc.cam.ac.uk\/structures\u201cAccess Structures service."}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202401874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:10:35Z","timestamp":1760299835000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202401874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,23]]},"references-count":52,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2024,8,12]]}},"alternative-id":["10.1002\/chem.202401874"],"URL":"https:\/\/doi.org\/10.1002\/chem.202401874","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"type":"print","value":"0947-6539"},{"type":"electronic","value":"1521-3765"}],"subject":[],"published":{"date-parts":[[2024,7,23]]},"assertion":[{"value":"2024-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202401874"}}