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Highly efficient reactions were successfully run with a wide range of bases including organic (DBU, LiTMP, <jats:italic>t<\/jats:italic>\u2010BuOK) and inorganic (NaOH, K<jats:sub>2<\/jats:sub>CO<jats:sub>3<\/jats:sub>) ones in ChCl\/Gly 1\u2009:\u20092 (mol\/mol) as solvent under mild conditions, at room temperature and under air. The proposed protocol was applied to a wide range of substrates, including (hetero)aromatic aldehydes with substituents as halogens (I, Br, Cl), EDG (alkoxy, methyl), EWG (NO<jats:sub>2<\/jats:sub>, CF<jats:sub>3<\/jats:sub>) or reactive groups as CN, esters, and ketones. Vinylic, alkynyl and cycloalkyl, alicyclic and \u03b1,\u03b2\u2010unsaturated aldehydes can also be used. Highly electrophilic ketones gave good yields. The diastereoselectivity of the reaction is in complete agreement with the <jats:italic>E<\/jats:italic>\/<jats:italic>Z<\/jats:italic> ratio predictable under traditional conditions. We demonstrated that the protocol is scalable to 2\u2005g (5\u2005mmol) of phosphonium salt, furthermore the proposed workup protocol allows to remove TPPO without need of additional chromatographic purification.<\/jats:p>","DOI":"10.1002\/chem.202402090","type":"journal-article","created":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T22:15:21Z","timestamp":1719785721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Wittig Reaction in Deep Eutectic Solvents: Expanding the DES Toolbox in Synthesis"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8703-3929","authenticated-orcid":false,"given":"Federica","family":"De Nardi","sequence":"first","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 di Torino  Via Pietro Giuria 7 I-10125 Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6049-9787","authenticated-orcid":false,"given":"Giulia","family":"Gorreta","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 di Torino  Via Pietro Giuria 7 I-10125 Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7564-3065","authenticated-orcid":false,"given":"Carolina","family":"Meazzo","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 di Torino  Via Pietro Giuria 7 I-10125 Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-4284","authenticated-orcid":false,"given":"Stefano","family":"Parisotto","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 di Torino  Via Pietro Giuria 7 I-10125 Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6553-8846","authenticated-orcid":false,"given":"Marco","family":"Blangetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 di Torino  Via Pietro Giuria 7 I-10125 Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9510-8783","authenticated-orcid":false,"given":"Cristina","family":"Prandi","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 di Torino  Via Pietro Giuria 7 I-10125 Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_2_10_1_1","unstructured":"\u00a0"},{"key":"e_1_2_10_2_2","first-page":"7108","volume":"41","author":"Zhang Q.","year":"2012","journal-title":"Chem. 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