{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:22:02Z","timestamp":1789834922914,"version":"4.0.1"},"reference-count":171,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL151333"],"award-info":[{"award-number":["P01 HL151333"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R61 HL181613"],"award-info":[{"award-number":["R61 HL181613"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2024,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nature offers a variety of structurally unique, sulfated endobiotics including sulfated glycosaminoglycans, sulfated tyrosine peptides, sulfated steroids\/bile acids\/catecholamines. Sulfated molecules display a large number of biological activities including antithrombotic, antimicrobial, anticancer, anti\u2010inflammatory, and others, which arise from modulation of intracellular signaling and enhanced <jats:italic>in\u2005vivo<\/jats:italic> retention of certain hormones. These characteristics position sulfated molecules very favorably as drug\u2010like agents. However, few have reached the clinic. Major hurdles exist in realizing sulfated molecules as drugs. This state\u2010of\u2010the\u2010art has been transformed through recent works on the development of sulfate masking technologies for both alkyl (sulfated carbohydrates, sulfated steroids) and aryl (sTyr\u2010bearing peptides\/proteins, sulfated flavonoids) sulfates. This review compiles the literature on different strategies implemented for different types of sulfate groups. Starting from early efforts in protection of sulfate groups to the design of newer SuFEx, trichloroethyl, and gem\u2010dimethyl\u2010based protection technologies, this review presents the evolution and application of concepts in realizing highly diverse, sulfated molecules as candidate drugs and\/or prodrugs. Overall, the newer strategies for sulfate masking and demasking are likely to greatly enhance the design and development of sulfated molecules as non\u2010toxic drugs of the future.<\/jats:p>","DOI":"10.1002\/chem.202402268","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T11:54:01Z","timestamp":1721303641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis and Reactivity of Masked Organic Sulfates"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6257-1456","authenticated-orcid":false,"given":"Bharath","family":"Kumar Villuri","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry School of Pharmacy Virginia Commonwealth University  Richmond, Virginia 23298 United States"},{"name":"Institute for Structural Biology Drug Discovery and Development Virginia Commonwealth University  Richmond, Virginia 23219 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1976-6597","authenticated-orcid":false,"given":"Umesh R.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry School of Pharmacy Virginia Commonwealth University  Richmond, Virginia 23298 United States"},{"name":"Institute for Structural Biology Drug Discovery and Development Virginia Commonwealth University  Richmond, Virginia 23219 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"e_1_2_4_1_1","unstructured":"C.\u2005L.\u2005R. Merry U. Lindahl J. Couchman J.\u2005D. Esko In Essentials of Glycobiology 4th edition(Eds: A. Varki R.\u2005D. Cummings J.\u2005D. Esko P. Stanley G.\u2005W. Hart M. Aebi D. Mohnen T. Kinoshita N.\u2005H. Packer J.\u2005H. Prestegard R.\u2005L. Schnaar P.\u2005H. Seeberger) Cold Spring Harbor Laboratory Press NewYork2022 pp. 217\u2013231 10.1101\/9781621824213."},{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/b100916h"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.4161\/cib.4.2.14547"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10163"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220333"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12832"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2019.02.004"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.05.017"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202211320"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1043713"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202212636"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.03.004"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(00)00093-4"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20022138"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2020.05.007"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.047"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:19:3:333"},{"key":"e_1_2_4_18_1","doi-asserted-by":"crossref","unstructured":"F. Monigatti E. Gasteiger A. Bairoch E. Jung 2002 5 769\u2013770.10.1093\/bioinformatics\/18.5.769.","DOI":"10.1093\/bioinformatics\/18.5.769"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602732200"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00388"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2008.12.007"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00027.x"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R300005-JLR200"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1081\/DMR-200033475"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.7.5864"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.943"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2001-0040"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1081\/DMR-200033496"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920006778520552"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920021501140218125020"},{"key":"e_1_2_4_31_1","doi-asserted-by":"crossref","unstructured":"J.\u2005A. Forrest J.\u2005A. Clements L.\u2005F. Prescott.1982 7 93\u2013107 10.2165\/00003088-198207020-00001.","DOI":"10.2165\/00003088-198207020-00001"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1945527"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14642"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.09.012"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(00)00202-7"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.5.9141497"},{"key":"e_1_2_4_37_1","doi-asserted-by":"crossref","unstructured":"M. Correia-da-Silva E. Sousa B. Duarte F. Marques F. Carvalho L.\u2005M. Cunha-Ribeiro M.\u2005M. Pinto J Med Chem.2011 54 5373\u201384.10.1021\/jm2006589.","DOI":"10.1021\/jm2006589"},{"key":"e_1_2_4_38_1","doi-asserted-by":"crossref","unstructured":"M. Correia-da-Silva E. Sousa M.\u2005M. Pinto.Med Res Rev.2014 34 223\u201379.10.1002\/med.21282.","DOI":"10.1002\/med.21282"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00132"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.1c01293"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.11.007"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(01)00417-4"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081963"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-0104"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb500402f"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-34521-1_19"},{"key":"e_1_2_4_47_1","doi-asserted-by":"crossref","unstructured":"N.\u2005S. Gandhi R.\u2005L. Mancera.Drug Discov Today.2010 23 1058\u201369.10.1016\/j.drudis.2010.10.009.Erratum in: Drug Discov Today.2011 16 741.","DOI":"10.1016\/j.drudis.2010.10.009"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13050760"},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00379"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00132"},{"key":"e_1_2_4_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00156"},{"key":"e_1_2_4_52_1","unstructured":"Multiple clinical trials. Seehttps:\/\/clinicaltrials.gov\/search?intr=muparfostatandhttps:\/\/clinicaltrials.gov\/search?intr=PI-88. Accessed 18 Jan. 2024."},{"key":"e_1_2_4_53_1","unstructured":"Multiple clinical trials. Seehttps:\/\/clinicaltrials.gov\/search?intr=PG545andhttps:\/\/clinicaltrials.gov\/search?intr=pixatimod. Accessed 18 Jan. 2024."},{"key":"e_1_2_4_54_1","doi-asserted-by":"crossref","unstructured":"S.\u2005D. Vallet C. Berthollier S. Ricard-Blum 2022 322 C1271-C1278.10.1152\/ajpcell.00095.2022.","DOI":"10.1152\/ajpcell.00095.2022"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155420946403"},{"key":"e_1_2_4_56_1","unstructured":"F.\u2005J. Gonzalez R.\u2005H. Tukey.Drug Metabolism. In Goodman & Gilman's The Pharmacological Basis of Therapeutics(Eds. Brunton LL Lazo JS Parker KL). 11thEdition. McGraw-Hill Medical Publishing Div. New York.2006 p. 82."},{"key":"e_1_2_4_57_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.115.067397"},{"key":"e_1_2_4_58_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.036566"},{"key":"e_1_2_4_59_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557522666220919125817"},{"key":"e_1_2_4_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.839887"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106862"},{"key":"e_1_2_4_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2019.140301"},{"key":"e_1_2_4_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav8075"},{"key":"e_1_2_4_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14606"},{"key":"e_1_2_4_65_1","doi-asserted-by":"publisher","DOI":"10.1139\/v78-385"},{"key":"e_1_2_4_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01511"},{"key":"e_1_2_4_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048632"},{"key":"e_1_2_4_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2010.02.015"},{"key":"e_1_2_4_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00010"},{"key":"e_1_2_4_70_1","first-page":"3238","volume":"21","author":"Pongener I.","year":"2021","journal-title":"Chem Rev."},{"key":"e_1_2_4_71_1","doi-asserted-by":"publisher","DOI":"10.1039\/P19900001739"},{"key":"e_1_2_4_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(00)00041-9"},{"key":"e_1_2_4_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2016.06.010"},{"key":"e_1_2_4_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol052130o"},{"key":"e_1_2_4_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202211985"},{"key":"e_1_2_4_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol0359261"},{"key":"e_1_2_4_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14355"},{"key":"e_1_2_4_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol303270v"},{"key":"e_1_2_4_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c01881"},{"key":"e_1_2_4_80_1","doi-asserted-by":"crossref","unstructured":"S. Arungundram K. Al-Mafraji J. Asong F.\u2005E. Leach\u2005III I.\u2005J. Amster A. Venot J.\u2005E. Turnbull G.-J. Boons J. Am. Chem. Soc.2009 131 17394\u201317405.","DOI":"10.1021\/ja907358k"},{"key":"e_1_2_4_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1073"},{"key":"e_1_2_4_82_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2014.877834"},{"key":"e_1_2_4_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2016.12.004"},{"key":"e_1_2_4_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301338q"},{"key":"e_1_2_4_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b00344"},{"key":"e_1_2_4_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol500738g"},{"key":"e_1_2_4_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.01.022"},{"key":"e_1_2_4_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201210132"},{"key":"e_1_2_4_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1398-6_26"},{"key":"e_1_2_4_90_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CC48860H"},{"key":"e_1_2_4_91_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2QO00439A"},{"key":"e_1_2_4_92_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB02756K"},{"key":"e_1_2_4_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol035882w"},{"key":"e_1_2_4_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00153a011"},{"key":"e_1_2_4_95_1","doi-asserted-by":"crossref","unstructured":"K. Weisenberger D. Mayer S.\u2005R. Sandler Dialkyl Sulfates and Alkylsulfuric Acidsullmann's Encyclopedia Ofindustrial Chemistry Wiley-VCH Weinheim Germany2000.","DOI":"10.1002\/14356007.a08_493"},{"key":"e_1_2_4_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01669a028"},{"key":"e_1_2_4_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46214-x"},{"key":"e_1_2_4_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00230a045"},{"key":"e_1_2_4_99_1","doi-asserted-by":"crossref","unstructured":"A. Foster E. Hancock J. Chem. Soc. (Resumed)1957 968\u2013970.","DOI":"10.1039\/JR9570000968"},{"key":"e_1_2_4_100_1","doi-asserted-by":"crossref","unstructured":"A. Foster E. Hancock W. Overend J. Robb J. Chem. Soc. (Resumed)1956 2589\u20132592.","DOI":"10.1039\/jr9560002589"},{"key":"e_1_2_4_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(00)80853-8"},{"key":"e_1_2_4_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-4166(00)86292-8"},{"key":"e_1_2_4_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(89)84145-X"},{"key":"e_1_2_4_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202007211"},{"key":"e_1_2_4_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo981163x"},{"key":"e_1_2_4_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(96)02302-7"},{"key":"e_1_2_4_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja056086j"},{"key":"e_1_2_4_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(97)01681-X"},{"key":"e_1_2_4_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2004.06.131"},{"key":"e_1_2_4_110_1","first-page":"533","volume-title":"Greene's Protective Groups in Organic Synthesis","author":"Green T. W.","year":"2007"},{"key":"e_1_2_4_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol036157o"},{"key":"e_1_2_4_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200600153"},{"key":"e_1_2_4_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo9014112"},{"key":"e_1_2_4_114_1","doi-asserted-by":"crossref","unstructured":"K. Fukuhara N. Shimada T. Nishino E. Kaji K. Makino Eur. J. Org. Chem.2016 902\u2013905.","DOI":"10.1002\/ejoc.201501568"},{"key":"e_1_2_4_115_1","doi-asserted-by":"publisher","DOI":"10.1039\/B610499A"},{"key":"e_1_2_4_116_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC05932C"},{"key":"e_1_2_4_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.103464"},{"key":"e_1_2_4_118_1","doi-asserted-by":"crossref","unstructured":"W. Chan P. White Fmoc Solid Phase Peptide Synthesis: A Practical Approach Oxford University Press1999.","DOI":"10.1093\/oso\/9780199637256.001.0001"},{"key":"e_1_2_4_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200805642"},{"key":"e_1_2_4_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201309399"},{"key":"e_1_2_4_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201403758"},{"key":"e_1_2_4_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201509016"},{"key":"e_1_2_4_123_1","doi-asserted-by":"crossref","unstructured":"G. Ren Q. Zheng H. Wang Org Lett.2017 19 1582\u20131585.10.1021\/acs.orglett.7b00406. Epub2017Erratum in:Org Lett.2017 19 2462.","DOI":"10.1021\/acs.orglett.7b00406"},{"key":"e_1_2_4_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b02522"},{"key":"e_1_2_4_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201712429"},{"key":"e_1_2_4_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b03950"},{"key":"e_1_2_4_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.202300020"},{"key":"e_1_2_4_128_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC02659B"},{"key":"e_1_2_4_129_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9OB00903E"},{"key":"e_1_2_4_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202207456"},{"key":"e_1_2_4_131_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c09306"},{"key":"e_1_2_4_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c07937"},{"key":"e_1_2_4_133_1","doi-asserted-by":"crossref","unstructured":"C.\u2005C. Liu E. Brustad W. Liu P.\u2005G. Schultz J. Am. Chem. Soc.2007 129 10648\u201310649.10.1021\/ja0735002.","DOI":"10.1021\/ja0735002"},{"key":"e_1_2_4_134_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.1160755"},{"key":"e_1_2_4_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.11.027"},{"key":"e_1_2_4_136_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00255"},{"key":"e_1_2_4_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200300631"},{"key":"e_1_2_4_138_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3011.2000.00746.x"},{"key":"e_1_2_4_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-017-1854-1"},{"key":"e_1_2_4_140_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi101240v"},{"key":"e_1_2_4_141_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb400274z"},{"key":"e_1_2_4_142_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-10-43"},{"key":"e_1_2_4_143_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CC14773K"},{"key":"e_1_2_4_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb500337r"},{"key":"e_1_2_4_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2020.10.002"},{"key":"e_1_2_4_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21720"},{"key":"e_1_2_4_147_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020396"},{"key":"e_1_2_4_148_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e31826aef4a"},{"key":"e_1_2_4_149_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2019.1558399"},{"key":"e_1_2_4_150_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2011.641532"},{"key":"e_1_2_4_151_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC06410A"},{"key":"e_1_2_4_152_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01279"},{"key":"e_1_2_4_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112829"},{"key":"e_1_2_4_154_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01389"},{"key":"e_1_2_4_155_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.9b00534"},{"key":"e_1_2_4_156_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr940337h"},{"key":"e_1_2_4_157_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2sc20536j"},{"key":"e_1_2_4_158_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c00980"},{"key":"e_1_2_4_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201101108"},{"key":"e_1_2_4_160_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666181120101147"},{"key":"e_1_2_4_161_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020480"},{"key":"e_1_2_4_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2007.07.100"},{"key":"e_1_2_4_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.11.060"},{"key":"e_1_2_4_164_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.9b00340"},{"key":"e_1_2_4_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11976-2"},{"key":"e_1_2_4_166_1","doi-asserted-by":"crossref","unstructured":"M. Pascolutti R.\u2005J. Quinn Drug Discov Today.2014 19 215\u201321.10.1016\/j.drudis.2013.10.013.","DOI":"10.1016\/j.drudis.2013.10.013"},{"key":"e_1_2_4_167_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171619"},{"key":"e_1_2_4_168_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18044739"},{"key":"e_1_2_4_169_1","doi-asserted-by":"publisher","DOI":"10.1021\/cc070009y"},{"key":"e_1_2_4_170_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00751"},{"key":"e_1_2_4_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07618-8"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202402268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T21:54:47Z","timestamp":1760306087000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202402268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,9]]},"references-count":171,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2024,9,16]]}},"alternative-id":["10.1002\/chem.202402268"],"URL":"https:\/\/doi.org\/10.1002\/chem.202402268","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,9]]},"assertion":[{"value":"2024-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202402268"}}