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Early prevention of such aggregation should alleviate disease condition by applying small molecule compounds that shift the aggregation equilibrium toward the soluble form of the peptide or slow down the process. We have discovered that fluorinated benzenesulfonamides of particular structure slowed the amyloid\u2010beta peptide aggregation process by more than three\u2010fold. We synthesized a series of <jats:italic>ortho\u2010para<\/jats:italic> and <jats:italic>meta\u2010para<\/jats:italic> double\u2010substituted fluorinated benzenesulfonamides that inhibited the aggregation process to a variable extent yielding a detailed picture of the structure\u2010activity relationship. Analysis of compound chemical structure effect on aggregation in artificial cerebrospinal fluid showed the necessity to arrange the benzenesulfonamide, hydrophobic substituent, and benzoic acid in a particular way. The amyloid beta peptide aggregate fibril structures varied in cross\u2010sectional height depending on the applied inhibitor indicating the formation of a complex with the compound. Application of selected inhibitors increased the survivability of cells affected by the amyloid beta peptide. Such compounds may be developed as drugs against Alzheimer's disease.<\/jats:p>","DOI":"10.1002\/chem.202402330","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T07:00:47Z","timestamp":1723014047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Structure\u2010Activity Relationship of Fluorinated Benzenesulfonamides as Inhibitors of Amyloid\u2010\u03b2 Aggregation"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2327-574X","authenticated-orcid":false,"given":"Mantas","family":"\u017dvirblis","sequence":"first","affiliation":[{"name":"Department of Biothermodynamics and Drug Design Institute of Biotechnology Life Sciences Center Vilnius University  Saul\u0117tekio av. 7 Vilnius LT-10257 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