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The optimal catalyst enables a one\u2010pot, metal\u2010free, catalytic protocol from allylic alcohols to \u03b3,\u03b4\u2010unsaturated ketones. The optimized process tolerates a range of substrates, including substituents with acid\u2010labile protecting groups. Reaction monitoring and DFT studies of the aliphatic ketone Claisen process agree that the ultimate rearrangement step typically has the highest activation barrier.<\/jats:p>","DOI":"10.1002\/chem.202402371","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T12:44:24Z","timestamp":1721393064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aliphatic Ketone Claisen Rearrangement: Troubleshooting the Transetherification Step by Identifying a Stable Acid Catalyst"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8854-0334","authenticated-orcid":false,"given":"Veera K.","family":"Bruce","sequence":"first","affiliation":[{"name":"Department of Chemistry and NanoScience Center University of Jyv\u00e4skyl\u00e4  P.O. 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