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Yet their synthesis is a tremendous challenge due to their high reactivity, typically leading to overmethylation. In this contribution, a highly selective catalytic\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methylation methodology is reported, converting urea derivatives to monomethylated amines, using a commercially available heterogeneous Pd\/C catalyst and methanol as unique reagent. Methanol provides a sustainable alternative protocol for the selective preparation of mono\u2010methylated derivatives as it acts as both H\n                    <jats:sub>2<\/jats:sub>\n                    and C1 sources. In addition, several control experiments were performed to provide a proposal for the mechanism, namely dehydrogenation of methanol and subsequent hydrogenation of urea derivatives, followed by reduction of the\n                    <jats:italic>in\u2005situ<\/jats:italic>\n                    formed methyl imine. Importantly, the approach is simple, highly productive and enables novel synthetic procedures for the preparation of monomethylamines from urea derivatives.\n                  <\/jats:p>","DOI":"10.1002\/chem.202402414","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T03:09:12Z","timestamp":1724900952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pd\/C\u2013Catalyzed Selective\n                    <i>N<\/i>\n                    \u2010Monomethylation by Transfer Hydrogenation of Urea Derivatives using Methanol as H\n                    <sub>2<\/sub>\n                    and C1 Sources"],"prefix":"10.1002","volume":"30","author":[{"given":"Kiruthigadevi","family":"Kamaraj","sequence":"first","affiliation":[{"name":"School of Advanced Sciences Department of Chemistry Vellore Institute of Technology  Vellore 632014 Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"H. 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