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Multifunctional Molecules (MFMs) specifically designed to address other contributing factors, such as metal ion induced abnormalities, oxidative stress, toxic A\u03b2 aggregates etc. are very much required. Several multifunctional molecules have been developed using different molecular scaffolds. Reported herein is a new series of four MFMs based on ThT, Azo\u2010stilbene and metal ion chelating pockets. The synthesis, characterization, and metal chelation ability for [Cu\n                    <jats:sup>2+<\/jats:sup>\n                    and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    ] are presented herein. Furthermore, we explored their multifunctionality w.r.t. to their (i) recognition of A\u03b2 aggregates and monomeric form, (ii) utility in modulating the aggregation pathways of both metal\u2010free and metal\u2010bound amyloid\u2010\u03b2, (iii) ex\u2010vivo staining of amyloid plaques in 5xFAD mice brain sections, (iv) ability to scavenge free radicals and (v) ability to inhibit cholinesterase activity. Molecular docking studies were also performed with A\u03b2 peptides and acetylcholinesterase enzyme to understand the observed inhibitory effect on activity. Overall, the studies presented here establish the multifunctional nature of these molecules and qualify them as promising candidates for furthermore investigation in the quest for finding Alzheimer's disease treatment.\n                  <\/jats:p>","DOI":"10.1002\/chem.202402748","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T12:03:33Z","timestamp":1730289813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of Anti\u2010Alzheimer's Potential of Azo\u2010Stilbene\u2010Thioflavin\u2010T derived Multifunctional Molecules: Synthesis, Metal and A\u03b2 Species Binding and Cholinesterase Activity"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2777-663X","authenticated-orcid":false,"given":"Monika","family":"Rana","sequence":"first","affiliation":[{"name":"Department of Chemistry Central University of Rajasthan  Bandarsindri, Ajmer 305817 India"},{"name":"Department of Chemistry University of Illinois at Urbana-Champaign  600 S. 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