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Mushrooms are a rich source of ligninolytic and secondary metabolite biosynthetic enzymes, and therefore were considered promising biocatalysts for organic synthesis. This review focuses on the broad utilization potential of mushroom\u2010based biocatalysts and highlights key advances in mushroom\u2010mediated redox reactions. It mainly includes the reduction of ketones and carboxylic acids, hydroxylation of aromatic and aliphatic compounds, epoxidation of olefins, oxidative cleavage of alkenes, and other uncommon reactions catalyzed by the whole cells or purified enzymes of mushroom origin. 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