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Different from the principle of action of antibiotics, AMPs have a better effect on resisting drug\u2010resistant bacteria. We synthesized a peptide library using solid\u2010phase synthesis and successfully screened the antimicrobial peptide RKGAK. AMPs provide effective defense against both bacteria and fungi. Research has found that the lowest inhibitory concentrations of RKGAK against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ,\n                    <jats:italic>E. coli<\/jats:italic>\n                    , and\n                    <jats:italic>C. albicans<\/jats:italic>\n                    are 75 \u03bcg\/mL, 100 \u03bcg\/mL, and 300 \u03bcg\/mL. Not only that, this antibacterial peptide also has certain antiviral and coagulation effects. It is a multifunctional peptide that has great potential in many biomedical fields. It also has the advantages of being less likely to develop drug resistance, low hemolytic activity and low cytotoxicity. Loading the peptide into hydrogels has achieved good results in applications that promote wound healing.\n                  <\/jats:p>","DOI":"10.1002\/chem.202403214","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:28:29Z","timestamp":1734136109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Screening of an Antibacterial and Coagulation Multifunctional Peptide and Its Application in Wound Healing"],"prefix":"10.1002","volume":"31","author":[{"given":"Shengjie","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering College of Materials Science and Engineering Institute of Biomedical Materials and Engineering Qingdao University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering College of Materials Science and Engineering Institute of Biomedical Materials and Engineering Qingdao University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering College of Materials Science and Engineering Institute of Biomedical Materials and Engineering Qingdao University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Cong","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering College of Materials Science and Engineering Institute of Biomedical Materials and Engineering Qingdao University  Qingdao 266071 China"},{"name":"State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao University  Qingdao 266071 China"},{"name":"School of Materials Science and Engineering Shandong University of Technology  Zibo 255000 China"},{"name":"Institute of Biomedical Materials and Engineering College of Chemistry and Chemical Engineering Qingdao University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-1118","authenticated-orcid":false,"given":"Bing","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering College of Materials Science and Engineering Institute of Biomedical Materials and Engineering Qingdao University  Qingdao 266071 China"},{"name":"State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao University  Qingdao 266071 China"},{"name":"Institute of Biomedical Materials and Engineering College of Chemistry and Chemical Engineering Qingdao University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,29]]},"reference":[{"key":"e_1_2_8_1_1","author":"Zeng J.","year":"2022","journal-title":"Nano Res."},{"key":"e_1_2_8_2_1","author":"Ma J.","year":"2022","journal-title":"WIREs Nanomed. 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